Histopathological assessment of depth of coagulation necrosis with Holmium, Moses, and Thulium fiber lasers in human prostate tissue.

Autor: Shah HN; Desai Sethi Urology Institute, University of Miami Miller School of Medicine, Miami, FL, USA. drhemendrashah@yahoo.co.in.; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA. drhemendrashah@yahoo.co.in., Arbelaez MCS; Desai Sethi Urology Institute, University of Miami Miller School of Medicine, Miami, FL, USA., Shah K; Desai Sethi Urology Institute, University of Miami Miller School of Medicine, Miami, FL, USA., Porto J; Desai Sethi Urology Institute, University of Miami Miller School of Medicine, Miami, FL, USA., Chanamolu DK; Desai Sethi Urology Institute, University of Miami Miller School of Medicine, Miami, FL, USA., Blachman-Braun R; Desai Sethi Urology Institute, University of Miami Miller School of Medicine, Miami, FL, USA., Hout M; Desai Sethi Urology Institute, University of Miami Miller School of Medicine, Miami, FL, USA., Smith NA; Desai Sethi Urology Institute, University of Miami Miller School of Medicine, Miami, FL, USA., Iakymenko OA; Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine, Miami, FL, USA., Kryvenko ON; Desai Sethi Urology Institute, University of Miami Miller School of Medicine, Miami, FL, USA.; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.; Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.; Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, FL, USA.
Jazyk: angličtina
Zdroj: World journal of urology [World J Urol] 2023 Nov; Vol. 41 (11), pp. 3059-3063. Date of Electronic Publication: 2023 Sep 26.
DOI: 10.1007/s00345-023-04617-3
Abstrakt: Purpose: To evaluate coagulation necrosis depth (CND) of Holmium (HL), Moses (ML), and Thulium fiber laser (TFL) in ex vivo human prostate tissue at various energy settings.
Methods: After endoscopic HL enucleation, small prostate tissue fragments were removed from the bladder with graspers and used for study. Immediately after surgery, a single incision was made on the surface of the tissue kept under normal saline at room temperature using a hand-held 550-µm laser fiber. Variable energy settings were tested for all three lasers. Two pathologists measured the CND with light microscopy using ocular micrometer. Impact of various laser settings on CND was analyzed. The differences in CND of all three lasers at similar laser power were compared.
Results: Mean CND was 0.56 ± 0.53 mm for long-pulse HL, 0.54 ± 0.53 mm for ML, 0.67 ± 0.67 mm for low-pulse TFL, and 0.81 ± 0.78 mm for high-pulse TFL. There was no significant difference between mean CND of HL and ML at various laser settings ranging from 10 to 120 W and CND with long- and short-pulse settings of TFL at settings from 10 to 60 W. There was a trend of increasing CND in HL and ML with increasing laser power; however, it was not statistically significant. TFL had similar tissue effects as HL and ML.
Conclusion: There is no significant difference in CND of HL, ML, and TFL in ex vivo human prostate tissue. Other factors besides laser type and settings need to be studied to explain clinical differences among various lasers used for prostate enucleation.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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