Association of Breast Cancer Odds with Background Parenchymal Enhancement Quantified Using a Fully Automated Method at MRI: The IMAGINE Study.

Autor: Watt GP; From the Department of Epidemiology and Biostatistics (G.P.W., P.P., M.W., X.L., M.C.P., J.L.B.), Department of Radiology (J.S.S., M.S.J.), and Department of Medical Physics (A.A.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, Perelman Center for Advanced Medicine at the University of Pennsylvania, Philadelphia, Pa (S.T., S.P.W., A.R.B., D.K.); Department of Medical Imaging, Zuyderland Medical Center, Sittard-Geleen, the Netherlands (M.B.I.L.); Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands (M.B.I.L.); GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (M.B.I.L.); Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (S.S.B.); and Department of Radiology, University of California Davis Medical Center, Davis, Calif (E.A.M.)., Thakran S; From the Department of Epidemiology and Biostatistics (G.P.W., P.P., M.W., X.L., M.C.P., J.L.B.), Department of Radiology (J.S.S., M.S.J.), and Department of Medical Physics (A.A.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, Perelman Center for Advanced Medicine at the University of Pennsylvania, Philadelphia, Pa (S.T., S.P.W., A.R.B., D.K.); Department of Medical Imaging, Zuyderland Medical Center, Sittard-Geleen, the Netherlands (M.B.I.L.); Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands (M.B.I.L.); GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (M.B.I.L.); Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (S.S.B.); and Department of Radiology, University of California Davis Medical Center, Davis, Calif (E.A.M.)., Sung JS; From the Department of Epidemiology and Biostatistics (G.P.W., P.P., M.W., X.L., M.C.P., J.L.B.), Department of Radiology (J.S.S., M.S.J.), and Department of Medical Physics (A.A.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, Perelman Center for Advanced Medicine at the University of Pennsylvania, Philadelphia, Pa (S.T., S.P.W., A.R.B., D.K.); Department of Medical Imaging, Zuyderland Medical Center, Sittard-Geleen, the Netherlands (M.B.I.L.); Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands (M.B.I.L.); GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (M.B.I.L.); Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (S.S.B.); and Department of Radiology, University of California Davis Medical Center, Davis, Calif (E.A.M.)., Jochelson MS; From the Department of Epidemiology and Biostatistics (G.P.W., P.P., M.W., X.L., M.C.P., J.L.B.), Department of Radiology (J.S.S., M.S.J.), and Department of Medical Physics (A.A.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, Perelman Center for Advanced Medicine at the University of Pennsylvania, Philadelphia, Pa (S.T., S.P.W., A.R.B., D.K.); Department of Medical Imaging, Zuyderland Medical Center, Sittard-Geleen, the Netherlands (M.B.I.L.); Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands (M.B.I.L.); GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (M.B.I.L.); Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (S.S.B.); and Department of Radiology, University of California Davis Medical Center, Davis, Calif (E.A.M.)., Lobbes MBI; From the Department of Epidemiology and Biostatistics (G.P.W., P.P., M.W., X.L., M.C.P., J.L.B.), Department of Radiology (J.S.S., M.S.J.), and Department of Medical Physics (A.A.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, Perelman Center for Advanced Medicine at the University of Pennsylvania, Philadelphia, Pa (S.T., S.P.W., A.R.B., D.K.); Department of Medical Imaging, Zuyderland Medical Center, Sittard-Geleen, the Netherlands (M.B.I.L.); Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands (M.B.I.L.); GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (M.B.I.L.); Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (S.S.B.); and Department of Radiology, University of California Davis Medical Center, Davis, Calif (E.A.M.)., Weinstein SP; From the Department of Epidemiology and Biostatistics (G.P.W., P.P., M.W., X.L., M.C.P., J.L.B.), Department of Radiology (J.S.S., M.S.J.), and Department of Medical Physics (A.A.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, Perelman Center for Advanced Medicine at the University of Pennsylvania, Philadelphia, Pa (S.T., S.P.W., A.R.B., D.K.); Department of Medical Imaging, Zuyderland Medical Center, Sittard-Geleen, the Netherlands (M.B.I.L.); Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands (M.B.I.L.); GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (M.B.I.L.); Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (S.S.B.); and Department of Radiology, University of California Davis Medical Center, Davis, Calif (E.A.M.)., Bradbury AR; From the Department of Epidemiology and Biostatistics (G.P.W., P.P., M.W., X.L., M.C.P., J.L.B.), Department of Radiology (J.S.S., M.S.J.), and Department of Medical Physics (A.A.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, Perelman Center for Advanced Medicine at the University of Pennsylvania, Philadelphia, Pa (S.T., S.P.W., A.R.B., D.K.); Department of Medical Imaging, Zuyderland Medical Center, Sittard-Geleen, the Netherlands (M.B.I.L.); Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands (M.B.I.L.); GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (M.B.I.L.); Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (S.S.B.); and Department of Radiology, University of California Davis Medical Center, Davis, Calif (E.A.M.)., Buys SS; From the Department of Epidemiology and Biostatistics (G.P.W., P.P., M.W., X.L., M.C.P., J.L.B.), Department of Radiology (J.S.S., M.S.J.), and Department of Medical Physics (A.A.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, Perelman Center for Advanced Medicine at the University of Pennsylvania, Philadelphia, Pa (S.T., S.P.W., A.R.B., D.K.); Department of Medical Imaging, Zuyderland Medical Center, Sittard-Geleen, the Netherlands (M.B.I.L.); Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands (M.B.I.L.); GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (M.B.I.L.); Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (S.S.B.); and Department of Radiology, University of California Davis Medical Center, Davis, Calif (E.A.M.)., Morris EA; From the Department of Epidemiology and Biostatistics (G.P.W., P.P., M.W., X.L., M.C.P., J.L.B.), Department of Radiology (J.S.S., M.S.J.), and Department of Medical Physics (A.A.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, Perelman Center for Advanced Medicine at the University of Pennsylvania, Philadelphia, Pa (S.T., S.P.W., A.R.B., D.K.); Department of Medical Imaging, Zuyderland Medical Center, Sittard-Geleen, the Netherlands (M.B.I.L.); Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands (M.B.I.L.); GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (M.B.I.L.); Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (S.S.B.); and Department of Radiology, University of California Davis Medical Center, Davis, Calif (E.A.M.)., Apte A; From the Department of Epidemiology and Biostatistics (G.P.W., P.P., M.W., X.L., M.C.P., J.L.B.), Department of Radiology (J.S.S., M.S.J.), and Department of Medical Physics (A.A.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, Perelman Center for Advanced Medicine at the University of Pennsylvania, Philadelphia, Pa (S.T., S.P.W., A.R.B., D.K.); Department of Medical Imaging, Zuyderland Medical Center, Sittard-Geleen, the Netherlands (M.B.I.L.); Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands (M.B.I.L.); GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (M.B.I.L.); Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (S.S.B.); and Department of Radiology, University of California Davis Medical Center, Davis, Calif (E.A.M.)., Patel P; From the Department of Epidemiology and Biostatistics (G.P.W., P.P., M.W., X.L., M.C.P., J.L.B.), Department of Radiology (J.S.S., M.S.J.), and Department of Medical Physics (A.A.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, Perelman Center for Advanced Medicine at the University of Pennsylvania, Philadelphia, Pa (S.T., S.P.W., A.R.B., D.K.); Department of Medical Imaging, Zuyderland Medical Center, Sittard-Geleen, the Netherlands (M.B.I.L.); Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands (M.B.I.L.); GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (M.B.I.L.); Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (S.S.B.); and Department of Radiology, University of California Davis Medical Center, Davis, Calif (E.A.M.)., Woods M; From the Department of Epidemiology and Biostatistics (G.P.W., P.P., M.W., X.L., M.C.P., J.L.B.), Department of Radiology (J.S.S., M.S.J.), and Department of Medical Physics (A.A.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, Perelman Center for Advanced Medicine at the University of Pennsylvania, Philadelphia, Pa (S.T., S.P.W., A.R.B., D.K.); Department of Medical Imaging, Zuyderland Medical Center, Sittard-Geleen, the Netherlands (M.B.I.L.); Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands (M.B.I.L.); GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (M.B.I.L.); Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (S.S.B.); and Department of Radiology, University of California Davis Medical Center, Davis, Calif (E.A.M.)., Liang X; From the Department of Epidemiology and Biostatistics (G.P.W., P.P., M.W., X.L., M.C.P., J.L.B.), Department of Radiology (J.S.S., M.S.J.), and Department of Medical Physics (A.A.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, Perelman Center for Advanced Medicine at the University of Pennsylvania, Philadelphia, Pa (S.T., S.P.W., A.R.B., D.K.); Department of Medical Imaging, Zuyderland Medical Center, Sittard-Geleen, the Netherlands (M.B.I.L.); Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands (M.B.I.L.); GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (M.B.I.L.); Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (S.S.B.); and Department of Radiology, University of California Davis Medical Center, Davis, Calif (E.A.M.)., Pike MC; From the Department of Epidemiology and Biostatistics (G.P.W., P.P., M.W., X.L., M.C.P., J.L.B.), Department of Radiology (J.S.S., M.S.J.), and Department of Medical Physics (A.A.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, Perelman Center for Advanced Medicine at the University of Pennsylvania, Philadelphia, Pa (S.T., S.P.W., A.R.B., D.K.); Department of Medical Imaging, Zuyderland Medical Center, Sittard-Geleen, the Netherlands (M.B.I.L.); Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands (M.B.I.L.); GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (M.B.I.L.); Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (S.S.B.); and Department of Radiology, University of California Davis Medical Center, Davis, Calif (E.A.M.)., Kontos D; From the Department of Epidemiology and Biostatistics (G.P.W., P.P., M.W., X.L., M.C.P., J.L.B.), Department of Radiology (J.S.S., M.S.J.), and Department of Medical Physics (A.A.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, Perelman Center for Advanced Medicine at the University of Pennsylvania, Philadelphia, Pa (S.T., S.P.W., A.R.B., D.K.); Department of Medical Imaging, Zuyderland Medical Center, Sittard-Geleen, the Netherlands (M.B.I.L.); Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands (M.B.I.L.); GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (M.B.I.L.); Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (S.S.B.); and Department of Radiology, University of California Davis Medical Center, Davis, Calif (E.A.M.)., Bernstein JL; From the Department of Epidemiology and Biostatistics (G.P.W., P.P., M.W., X.L., M.C.P., J.L.B.), Department of Radiology (J.S.S., M.S.J.), and Department of Medical Physics (A.A.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, Perelman Center for Advanced Medicine at the University of Pennsylvania, Philadelphia, Pa (S.T., S.P.W., A.R.B., D.K.); Department of Medical Imaging, Zuyderland Medical Center, Sittard-Geleen, the Netherlands (M.B.I.L.); Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands (M.B.I.L.); GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (M.B.I.L.); Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (S.S.B.); and Department of Radiology, University of California Davis Medical Center, Davis, Calif (E.A.M.).
Jazyk: angličtina
Zdroj: Radiology [Radiology] 2023 Sep; Vol. 308 (3), pp. e230367.
DOI: 10.1148/radiol.230367
Abstrakt: Background Background parenchymal enhancement (BPE) at breast MRI has been associated with increased breast cancer risk in several independent studies. However, variability of subjective BPE assessments have precluded its use in clinical practice. Purpose To examine the association between fully objective measures of BPE at MRI and odds of breast cancer. Materials and Methods This prospective case-control study included patients who underwent a bilateral breast MRI examination and were receiving care at one of three centers in the United States from November 2010 to July 2017. Breast volume, fibroglandular tissue (FGT) volume, and BPE were quantified using fully automated software. Fat volume was defined as breast volume minus FGT volume. BPE extent was defined as the proportion of FGT voxels with enhancement of 20% or more. Spearman rank correlation between quantitative BPE extent and Breast Imaging Reporting and Data System (BI-RADS) BPE categories assigned by an experienced board-certified breast radiologist was estimated. With use of multivariable logistic regression, breast cancer case-control status was regressed on tertiles (low, moderate, and high) of BPE, FGT volume, and fat volume, with adjustment for covariates. Results In total, 536 case participants with breast cancer (median age, 48 years [IQR, 43-55 years]) and 940 cancer-free controls (median age, 46 years [IQR, 38-55 years]) were included. BPE extent was positively associated with BI-RADS BPE ( r s = 0.54; P < .001). Compared with low BPE extent (range, 2.9%-34.2%), high BPE extent (range, 50.7%-97.3%) was associated with increased odds of breast cancer (odds ratio [OR], 1.74 [95% CI: 1.23, 2.46]; P for trend = .002) in a multivariable model also including FGT volume (OR, 1.39 [95% CI: 0.97, 1.98]) and fat volume (OR, 1.46 [95% CI: 1.04, 2.06]). The association of high BPE extent with increased odds of breast cancer was similar for premenopausal and postmenopausal women (ORs, 1.75 and 1.83, respectively; interaction P = .73). Conclusion Objectively measured BPE at breast MRI is associated with increased breast cancer odds for both premenopausal and postmenopausal women. Clinical trial registration no. NCT02301767 © RSNA, 2023 Supplemental material is available for this article. See also the editorial by Bokacheva in this issue.
Databáze: MEDLINE