Incidental Finding of Hepatic Inflammatory Pseudotumor Immunoglobulin G4-Related Disease With Underlying Chronic Hepatitis C.
| Autor: | Delbrune M; Gastroenterology, Hepatology and Nutrition, University of Minnesota, Minneapolis, USA., Wongjarupong N; Gastroenterology, Hepatology and Nutrition, University of Minnesota, Minneapolis, USA., Aby ES; Gastroenterology, Hepatology and Nutrition/ Transplant Hepatology, University of Minnesota, Minneapolis, USA., Iwamoto C; Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, USA., Hassan M; Gastroenterology, Hepatology and Nutrition, University of Minnesota, Minneapolis, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2023 Aug 24; Vol. 15 (8), pp. e44066. Date of Electronic Publication: 2023 Aug 24 (Print Publication: 2023). |
| DOI: | 10.7759/cureus.44066 |
| Abstrakt: | Immunoglobulin G4-related disease (IgG4-RD) is a unique immunological disease that can impact multiple organs including a formation of a hepatic inflammatory pseudotumor (IPT). We present a case of a 67-year-old male with a history of chronic viral hepatitis C infection who had an accidental finding on magnetic resonance imaging (MRI) of a liver arterially enhancing lesion. With an extensive work-up, immunohistochemical stains for immunoglobulin G of the liver lesion was performed and showed markedly increased IgG4-positive plasma cells (> 50/HPF), which was consistent with hepatic inflammatory pseudotumor related to IgG4-RD. The patient was treated with prednisone with a complete resolution of the hepatic lesion. The diagnosis of hepatic IPT and IgG4-RD requires a high degree of clinical suspicion and coordination with a multi-disciplinary team, including pathologists. Early tissue acquisition and staining for IgG4 was essential for the early diagnosis and treatment in this case. We also provide a comprehensive summary of published reports of IgG4-RD presenting with IPT. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2023, Delbrune et al.) |
| Databáze: | MEDLINE |
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