Simultaneous perfusion, diffusion, T 2 *, and T 1 mapping with MR fingerprinting.

Autor: Fan H; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Bunker L; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Wang Z; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Durfee AZ; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Lin D; The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Yedavalli V; The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Ge Y; Department of Radiology, New York University Grossman School of Medicine, New York, New York, USA., Zhou XJ; Department of Radiology, Center for Magnetic Resonance Research, University of Illinois at Chicago, Chicago, Illinois, USA., Hillis AE; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Lu H; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA.
Jazyk: angličtina
Zdroj: Magnetic resonance in medicine [Magn Reson Med] 2024 Feb; Vol. 91 (2), pp. 558-569. Date of Electronic Publication: 2023 Sep 25.
DOI: 10.1002/mrm.29880
Abstrakt: Purpose: Quantitative mapping of brain perfusion, diffusion, T 2 *, and T 1 has important applications in cerebrovascular diseases. At present, these sequences are performed separately. This study aims to develop a novel MRI technique to simultaneously estimate these parameters.
Methods: This sequence to measure perfusion, diffusion, T 2 *, and T 1 mapping with magnetic resonance fingerprinting (MRF) was based on a previously reported MRF-arterial spin labeling (ASL) sequence, but the acquisition module was modified to include different TEs and presence/absence of bipolar diffusion-weighting gradients. We compared parameters derived from the proposed method to those derived from reference methods (i.e., separate sequences of MRF-ASL, conventional spin-echo DWI, and T 2 * mapping). Test-retest repeatability and initial clinical application in two patients with stroke were evaluated.
Results: The scan time of our proposed method was 24% shorter than the sum of the reference methods. Parametric maps obtained from the proposed method revealed excellent image quality. Their quantitative values were strongly correlated with those from reference methods and were generally in agreement with values reported in the literature. Repeatability assessment revealed that ADC, T 2 *, T 1 , and B 1 + estimation was highly reliable, with voxelwise coefficient of variation (CoV) <5%. The CoV for arterial transit time and cerebral blood flow was 16% ± 3% and 25% ± 9%, respectively. The results from the two patients with stroke demonstrated that parametric maps derived from the proposed method can detect both ischemic and hemorrhagic stroke.
Conclusion: The proposed method is a promising technique for multi-parametric mapping and has potential use in patients with stroke.
(© 2023 International Society for Magnetic Resonance in Medicine.)
Databáze: MEDLINE
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