Glucagon-like peptide-1 and glucagon-like peptide-2 regulation during human liver regeneration.

Autor: Ammann M; Department of Surgery, State Hospital Wiener Neustadt, Wiener Neustadt, Austria.; Division of Visceral Surgery, Department of General Surgery, Medical University of Vienna, Vienna, Austria., Santol J; Department of Surgery, HPB Centre, Viennese Health Network, Clinic Favoriten and Sigmund Freud Private University, Vienna, Austria., Pereyra D; Division of Visceral Surgery, Department of General Surgery, Medical University of Vienna, Vienna, Austria., Kalchbrenner T; Department of Pathology, State Hospital Wiener Neustadt, Wiener Neustadt, Austria., Wuerger T; Department of Pathology, State Hospital Wiener Neustadt, Wiener Neustadt, Austria., Laengle J; Division of Visceral Surgery, Department of General Surgery, Medical University of Vienna, Vienna, Austria., Smoot RL; Department of Surgery, Division of Hepatobiliary and Pancreas Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN, USA., Hulla W; Department of Pathology, State Hospital Wiener Neustadt, Wiener Neustadt, Austria., Laengle F; Department of Surgery, State Hospital Wiener Neustadt, Wiener Neustadt, Austria., Starlinger P; Division of Visceral Surgery, Department of General Surgery, Medical University of Vienna, Vienna, Austria. starlinger.patrick@mayo.edu.; Department of Surgery, Division of Hepatobiliary and Pancreas Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN, USA. starlinger.patrick@mayo.edu.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Sep 25; Vol. 13 (1), pp. 15980. Date of Electronic Publication: 2023 Sep 25.
DOI: 10.1038/s41598-023-43283-8
Abstrakt: Accumulating evidence suggests that metabolic demands of the regenerating liver are met via lipid metabolism and critical regulators of this process. As such, glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2) critically affect hepatic regeneration in rodent models. The present study aimed to evaluate potential alterations and dynamics of circulating GLP-1 and GLP-2 in patients undergoing liver resections, focusing on post-hepatectomy liver failure (PHLF). GLP-1, GLP-2, Interleukin-6 (IL-6) and parameters of lipid metabolism were determined perioperatively in fasting plasma of 46 patients, who underwent liver resection. GLP-1 and GLP-2 demonstrated a rapid and consistently inverse time course during hepatic regeneration with a significant decrease of GLP-1 and increase of GLP-2 on POD1. Importantly, these postoperative dynamics were significantly more pronounced when PHLF occurred. Of note, the extent of resection or development of complications were not associated with these alterations. IL-6 mirrored the time course of GLP-2. Assessing the main degradation protein dipeptidyl peptidase 4 (DPP4) no significant association with either GLP-1 or -2 could be found. Additionally, in PHLF distinct postoperative declines in plasma lipid parameters were present and correlated with GLP-2 dynamics. Our data suggest dynamic inverse regulation of GLP-1 and GLP-2 during liver regeneration, rather caused by an increase in expression/release than by changes in degradation capacity and might be associated with inflammatory responses. Their close association with circulating markers of lipid metabolism and insufficient hepatic regeneration after liver surgery suggest a critical involvement during these processes in humans.
(© 2023. Springer Nature Limited.)
Databáze: MEDLINE
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