Gross and Histologic Placental Abnormalities Associated With Neonatal Hypoxic-Ischemic Encephalopathy.
| Autor: | Kim CF; Department of Pathology, Boston Children's Hospital, Boston, MA, USA.; Department of Pathology and Immunology, Texas Children's Hospital, Houston, TX, USA., Carreon CK; Department of Pathology, Boston Children's Hospital, Boston, MA, USA.; Department of Pathology, Harvard Medical School, Boston, MA, USA., James KE; Department of Obstetrics, Gynecology, and Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA., Bates SV; Department of Neonatology and Newborn Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Mueller SB; Department of Pathology, Harvard Medical School, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA., Boyd TK; Department of Pathology, Boston Children's Hospital, Boston, MA, USA.; Department of Pathology and Immunology, Texas Children's Hospital, Houston, TX, USA., Roberts DJ; Department of Pathology, Harvard Medical School, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society [Pediatr Dev Pathol] 2024 Mar-Apr; Vol. 27 (2), pp. 123-131. Date of Electronic Publication: 2023 Sep 25. |
| DOI: | 10.1177/10935266231195166 |
| Abstrakt: | Objective: To elucidate particular placental pathology findings that are associated with hypoxic ischemic encephalopathy (HIE) and determine which patterns are associated with adverse fetal/neonatal outcomes. Study Design: Multi-institutional retrospective case-control study of newborns with HIE (2002-2022) and controls. Four perinatal pathologists performed gross and histologic evaluation of placentas of cases and controls. Results: A total of 265 placentas of neonates with HIE and 122 controls were examined. Infants with HIE were more likely to have anatomic umbilical cord abnormalities (19.7% vs 7.4%, P = .003), fetal inflammatory response in the setting of amniotic fluid infection (27.7% vs 13.9%, P = .004), and fetal vascular malperfusion (30.6% vs 9.0%, P = <.001) versus controls. Fetal vascular malperfusion with maternal vascular malperfusion was more common in those who died of disease ( P = .01). Conclusion: Placental pathology examination of neonates with HIE may improve our understanding of this disorder and its adverse outcomes. Competing Interests: Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. |
| Databáze: | MEDLINE |
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