Placental Lesions Associated With Stillbirth by Gestational Age, as Related to Cause of Death: Follow-Up Results From the Stillbirth Collaborative Research Network.

Autor:	Cersonsky TEK; Warren Alpert Medical School of Brown University, Providence, RI, USA., Cersonsky RK; Department of Chemical and Biological Engineering, University of Wisconsin, Madison, WI, USA., Silver RM; Department of Obstetrics & Gynecology, University of Utah School of Medicine, Salt Lake City, UT, USA., Dudley DJ; Department of Obstetrics & Gynecology, University of Virginia, Charlottesville, VA, USA., Pinar H; Warren Alpert Medical School of Brown University, Providence, RI, USA.; Department of Pathology, Women and Infants Hospital of Rhode Island, Providence, RI, USA.
Jazyk:	angličtina
Zdroj:	Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society [Pediatr Dev Pathol] 2024 Jan-Feb; Vol. 27 (1), pp. 39-44. Date of Electronic Publication: 2023 Sep 25.
DOI:	10.1177/10935266231197349
Abstrakt:	Background: We previously identified placental lesions associated with stillbirths of varying gestational ages (GA) using advanced feature analysis. We further investigated the relationships between placental lesions and cause of death in stillbirths within these GA ranges. Methods: Using data from the Stillbirth Collaborative Research Network, we derived a sample of stillbirths who underwent placental examination and Initial Causes of Fetal Death (INCODE) evaluation for determining cause of death. We then compared the rates of causes of death within and among GA ranges (extreme preterm stillbirth [PTSB] [<28 weeks], early PTSB [28-33 6/7  weeks], late PTSB [34-36 6/7  weeks], term stillbirth [≥37 weeks]) according to the presence of these lesions. Results: We evaluated 352 stillbirths. In extreme PTSB, obstetric complications and infections were associated with acute funisitis. In early PTSB, uteroplacental insufficiency was associated with parenchymal infarcts. In term stillbirth (vs early PTSB), increased syncytial knots were associated with umbilical cord causes and infection. Conclusions: Placental lesions of high importance in distinguishing stillbirths at different GAs are associated with specific causes of death. This information is important in relating the presence of placental lesions and fetal death and in helping to understand etiologies of stillbirths at different GAs. Competing Interests: Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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