Host genetic variation at a locus near CHD1L impacts HIV sequence diversity in a South African population.

Autor:	Schulz VE; Department of Medical Microbiology and Infectious Diseases, University of Manitoba , Winnipeg, Manitoba, Canada.; Sexually Transmitted and Bloodborne Infections Division, JC Wilt Infectious Diseases Research Centre, National Microbiology Laboratories, Public Health Agency of Canada , Winnipeg, Manitoba, Canada., Tuff JF; Sexually Transmitted and Bloodborne Infections Division, JC Wilt Infectious Diseases Research Centre, National Microbiology Laboratories, Public Health Agency of Canada , Winnipeg, Manitoba, Canada., Tough RH; Department of Medical Microbiology and Infectious Diseases, University of Manitoba , Winnipeg, Manitoba, Canada.; Sexually Transmitted and Bloodborne Infections Division, JC Wilt Infectious Diseases Research Centre, National Microbiology Laboratories, Public Health Agency of Canada , Winnipeg, Manitoba, Canada., Lewis L; Centre for the AIDS Programme of Research in South Africa , Durban, South Africa., Chimukangara B; Centre for the AIDS Programme of Research in South Africa , Durban, South Africa.; Critical Care Medicine Department, NIH Clinical Center, National Institutes of Health , Bethesda, Maryland, USA.; Department of Virology, University of KwaZulu-Natal , Durban, South Africa., Garrett N; Centre for the AIDS Programme of Research in South Africa , Durban, South Africa.; Department of Public Health Medicine, School of Nursing and Public Health, University of KwaZulu-Natal , Durban, South Africa., Abdool Karim Q; Centre for the AIDS Programme of Research in South Africa , Durban, South Africa.; Department of Epidemiology, Mailman School of Public Health, Columbia University , New York, New York, USA., Abdool Karim SS; Centre for the AIDS Programme of Research in South Africa , Durban, South Africa.; Department of Epidemiology, Mailman School of Public Health, Columbia University , New York, New York, USA., McKinnon LR; Department of Medical Microbiology and Infectious Diseases, University of Manitoba , Winnipeg, Manitoba, Canada.; Centre for the AIDS Programme of Research in South Africa , Durban, South Africa., Kharsany ABM; Centre for the AIDS Programme of Research in South Africa , Durban, South Africa.; Department of Medical Microbiology, School of Laboratory Medicine and Medical Science, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal , Durban, South Africa., McLaren PJ; Department of Medical Microbiology and Infectious Diseases, University of Manitoba , Winnipeg, Manitoba, Canada.; Sexually Transmitted and Bloodborne Infections Division, JC Wilt Infectious Diseases Research Centre, National Microbiology Laboratories, Public Health Agency of Canada , Winnipeg, Manitoba, Canada.
Jazyk:	angličtina
Zdroj:	Journal of virology [J Virol] 2023 Oct 31; Vol. 97 (10), pp. e0095423. Date of Electronic Publication: 2023 Sep 25.
DOI:	10.1128/jvi.00954-23
Abstrakt:	Importance: It has been previously shown that genetic variants near CHD1L on chromosome 1 are associated with reduced HIV VL in African populations. However, the impact of these variants on viral diversity and how they restrict viral replication are unknown. We report on a regional association analysis in a South African population and show evidence of selective pressure by variants near CHD1L on HIV RT and gag. Our findings provide further insight into how genetic variability at this locus contributes to host control of HIV in a South African population. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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