Effect of ondansetron compared to lidocaine and placebo for reducing propofol injection pain: A systematic review and meta-analysis of randomized controlled trials.

Autor:	Zaazouee MS; Faculty of Medicine, Al-Azhar University, Assiut, Egypt., Mahmoud AM; Faculty of Medicine, Menoufia University, Menoufia, Egypt., Elfar WH; Faculty of Medicine, Al-Azhar University, Cairo, Egypt., Hana K; Faculty of Medicine, Assiut University, Assiut, Egypt., Shamshoon KF; Faculty of Medicine, Assiut University, Assiut, Egypt., Adly MH; Faculty of Medicine, Assiut University, Assiut, Egypt., Hussein TA; Faculty of Medicine, Assiut University, Assiut, Egypt., Hamza MM; Faculty of Medicine, Hashemite University, Zarqa, Jordan., Aly AA; Faculty of Medicine, Alexandria University, Alexandria, Egypt., Eguzo MA; Faculty of Medicine, Alexandria University, Alexandria, Egypt., Farhat AM; Faculty of Medicine, Fayoum University, Fayoum, Egypt., Elsnhory AB; Faculty of Medicine, Al-Azhar University, Cairo, Egypt., Morsy MH; Faculty of Medicine, Alexandria University, Alexandria, Egypt., Ammar MF; Faculty of Medicine, Tanta University, Tanta, Egypt., Alnaji AA; Faculty of Medicine, Fajr College for Science and Technology, Khartoum, Sudan., Elshanbary AA; Faculty of Medicine, Alexandria University, Alexandria, Egypt., Shah J; Kateb University, Medical Research Center, Kateb University, Kabul., AbdelQadir YH; Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Jazyk:	angličtina
Zdroj:	Medicine [Medicine (Baltimore)] 2023 Sep 22; Vol. 102 (38), pp. e35021.
DOI:	10.1097/MD.0000000000035021
Abstrakt:	Objective: Propofol is the most commonly used intravenous anesthetic medication and is most commonly associated with post-operative pain. Several drugs are investigated to reduce post-operative pain caused by propofol injection. Ondansetron is a potent anti-emetic drug showing promising results as an analgesic. This meta-analysis aims to compare the efficacy of ondansetron to placebo and lidocaine in reducing post-operative pain caused by propofol injection. Methods: PubMed, Embase, Cochrane Library, Web of Science, and Scopus were searched for relevant randomized controlled trials (RCTs) till May 2022. We conducted a meta-analysis using RevMan software version 5.4, and we assessed the quality of included RCTs using the Cochrane risk of bias tool. Results: In our study, we included 23 RCTs with 2957 participants. Compared to placebo, ondansetron significantly increased the rate of no pain [risk ratio (RR) = 2.36, 95% confidence interval (CI) (1.39-4.01)], and reduced moderate [RR = 0.39, 95% CI (0.30-0.52)] and severe pain [RR = 0.34, 95% CI (0.24-0.50)]. Furthermore, ondansetron significantly reduced PONV [RR = 0.73, 95% CI (0.58, 0.91)]. On the other hand, ondansetron showed an inferior efficacy to lidocaine regarding the incidence of no, moderate, and severe pain. Conclusion: Ondansetron is effective in reducing post-operative propofol-induced pain. However, lidocaine is more effective than it. Competing Interests: The authors have no funding and conflicts of interest to disclose. (Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
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