Probing the Relationship Between the Human Gut Microbiome and Prospects of Prostate Cancer: A Systematic Review.

Autor:	Makkena VK; Department of Internal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.; Department of Medicine, Osmania Medical College, Hyderabad, IND., Jaramillo AP; Department of Internal Medicine, Universidad Estatal de Guayaquil, Machala, ECU.; Department of Internal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA., Awosusi BL; Department of Pathology and Laboratory Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA., Ayyub J; Department of Internal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA., Dabhi KN; Department of Internal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA., Gohil NV; Department of Internal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.; Department of Internal Medicine, Medical College Baroda, Vadodara, IND., Tanveer N; Department of Internal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA., Hussein S; Department of Internal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA., Pingili S; Department of Internal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.; Department of Medicine, Kakatiya Medical College, Hyderabad, IND., Khan S; Department of Internal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2023 Aug 21; Vol. 15 (8), pp. e43892. Date of Electronic Publication: 2023 Aug 21 (Print Publication: 2023).
DOI:	10.7759/cureus.43892
Abstrakt:	Prostate neoplasia is one of the most commonly occurring neoplasias in males and has a high mortality rate. Prostate cancer (PCA) risk factors include tall stature, male sex, known family history, obesity, high blood pressure, lack of fitness, higher levels of testosterone for a long time, increasing age, and ethnicity are well known. The association and role of the gut microbiota in different diseases in our body have been highlighted recently. Therefore, finding the influence of gut microbiota on the prostatic cells can be useful for preventing prostatic neoplasia and/or reducing its severity. We aimed to assess its impact on PCA risk. We thoroughly searched databases for the relevant literature for our systematic review. The final research papers analyzed how bacteria played a role in the risk of PCA, either through inflammation or the production of metabolites that increase/decrease the risk of PCA. Based on the studies reviewed, we found that some gut bacteria play a role in the formation of PCA. In contrast, some bacteria can help prevent PCA, but the metabolism of the dietary components is the major factor for PCA. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2023, Makkena et al.)
Databáze:	MEDLINE
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