Role of cytokine in malignant T-cell metabolism and subsequent alternation in T-cell tumor microenvironment.

Autor:	Yadav M; Department of Forensic Science, Guru Ghasidas Vishwavidyalaya, Bilaspur, India., Uikey BN; Department of Forensic Science, Guru Ghasidas Vishwavidyalaya, Bilaspur, India., Rathore SS; Department of Forensic Science, Guru Ghasidas Vishwavidyalaya, Bilaspur, India., Gupta P; Department of Forensic Science, Guru Ghasidas Vishwavidyalaya, Bilaspur, India., Kashyap D; Department of Forensic Science, Guru Ghasidas Vishwavidyalaya, Bilaspur, India., Kumar C; Department of Forensic Science, Guru Ghasidas Vishwavidyalaya, Bilaspur, India., Shukla D; Department of Biotechnology, Guru Ghasidas Vishwavidyalaya, Bilaspur, India., Vijayamahantesh; Department of Immunology and Microbiology, University of Missouri, Columbia, SC, United States., Chandel AS; Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Bunkyo, Japan., Ahirwar B; Department of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur, India., Singh AK; Department of Microbiology, RK University, Rajkot, India., Suman SS; Department of Zoology, Udayana Charya (UR) College, Lalit Narayan Mithila University, Darbhanga, India., Priyadarshi A; Department of Zoology, Veer Kunwar Singh University, Arrah, India., Amit A; Department of Forensic Science, Guru Ghasidas Vishwavidyalaya, Bilaspur, India.
Jazyk:	angličtina
Zdroj:	Frontiers in oncology [Front Oncol] 2023 Sep 07; Vol. 13, pp. 1235711. Date of Electronic Publication: 2023 Sep 07 (Print Publication: 2023).
DOI:	10.3389/fonc.2023.1235711
Abstrakt:	T cells are an important component of adaptive immunity and T-cell-derived lymphomas are very complex due to many functional sub-types and functional elasticity of T-cells. As with other tumors, tissues specific factors are crucial in the development of T-cell lymphomas. In addition to neoplastic cells, T- cell lymphomas consist of a tumor micro-environment composed of normal cells and stroma. Numerous studies established the qualitative and quantitative differences between the tumor microenvironment and normal cell surroundings. Interaction between the various component of the tumor microenvironment is crucial since tumor cells can change the microenvironment and vice versa. In normal T-cell development, T-cells must respond to various stimulants deferentially and during these courses of adaptation. T-cells undergo various metabolic alterations. From the stage of quiescence to attention of fully active form T-cells undergoes various stage in terms of metabolic activity. Predominantly quiescent T-cells have ATP-generating metabolism while during the proliferative stage, their metabolism tilted towards the growth-promoting pathways. In addition to this, a functionally different subset of T-cells requires to activate the different metabolic pathways, and consequently, this regulation of the metabolic pathway control activation and function of T-cells. So, it is obvious that dynamic, and well-regulated metabolic pathways are important for the normal functioning of T-cells and their interaction with the microenvironment. There are various cell signaling mechanisms of metabolism are involved in this regulation and more and more studies have suggested the involvement of additional signaling in the development of the overall metabolic phenotype of T cells. These important signaling mediators include cytokines and hormones. The impact and role of these mediators especially the cytokines on the interplay between T-cell metabolism and the interaction of T-cells with their micro-environments in the context of T-cells lymphomas are discussed in this review article. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Yadav, Uikey, Rathore, Gupta, Kashyap, Kumar, Shukla, Vijayamahantesh, Chandel, Ahirwar, Singh, Suman, Priyadarshi and Amit.)
Databáze:	MEDLINE
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