Ancestral sequence reconstruction as a tool to study the evolution of wood decaying fungi.
| Autor: | Ayuso-Fernández I; Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences (NMBU), Ås, Norway., Molpeceres G; Centro de Investigaciones Biológicas 'Margarita Salas' (CIB), CSIC, Madrid, Spain., Camarero S; Centro de Investigaciones Biológicas 'Margarita Salas' (CIB), CSIC, Madrid, Spain., Ruiz-Dueñas FJ; Centro de Investigaciones Biológicas 'Margarita Salas' (CIB), CSIC, Madrid, Spain., Martínez AT; Centro de Investigaciones Biológicas 'Margarita Salas' (CIB), CSIC, Madrid, Spain. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in fungal biology [Front Fungal Biol] 2022 Oct 14; Vol. 3, pp. 1003489. Date of Electronic Publication: 2022 Oct 14 (Print Publication: 2022). |
| DOI: | 10.3389/ffunb.2022.1003489 |
| Abstrakt: | The study of evolution is limited by the techniques available to do so. Aside from the use of the fossil record, molecular phylogenetics can provide a detailed characterization of evolutionary histories using genes, genomes and proteins. However, these tools provide scarce biochemical information of the organisms and systems of interest and are therefore very limited when they come to explain protein evolution. In the past decade, this limitation has been overcome by the development of ancestral sequence reconstruction (ASR) methods. ASR allows the subsequent resurrection in the laboratory of inferred proteins from now extinct organisms, becoming an outstanding tool to study enzyme evolution. Here we review the recent advances in ASR methods and their application to study fungal evolution, with special focus on wood-decay fungi as essential organisms in the global carbon cycling. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Ayuso-Fernández, Molpeceres, Camarero, Ruiz-Dueñas and Martínez.) |
| Databáze: | MEDLINE |
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