Adipose transcriptome in the scalp of androgenetic alopecia.

Autor:	Cruz CJG; Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; International Center for Wound Repair and Regeneration, National Cheng Kung University, Tainan, Taiwan., Hong YK; Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; International Center for Wound Repair and Regeneration, National Cheng Kung University, Tainan, Taiwan., Aala WJF; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan., Tsai RY; Department of Dermatology and Skin Laser Center, Taipei Municipal Wan-Fang Hospital, Taipei Medical University, Taipei, Taiwan., Chung PL; Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan., Tsai YS; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan., Hsu CK; Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; International Center for Wound Repair and Regeneration, National Cheng Kung University, Tainan, Taiwan., Yang CC; Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; International Center for Wound Repair and Regeneration, National Cheng Kung University, Tainan, Taiwan.
Jazyk:	angličtina
Zdroj:	Frontiers in medicine [Front Med (Lausanne)] 2023 Sep 07; Vol. 10, pp. 1195656. Date of Electronic Publication: 2023 Sep 07 (Print Publication: 2023).
DOI:	10.3389/fmed.2023.1195656
Abstrakt:	Previous studies have shown how adipocytes can modulate the activity of hair follicle stem cells. However, the role of adipocytes in the pathogenesis of androgenetic alopecia (AGA) remains unknown. We aimed to determine signaling pathways related to the adipose tissue changes in the human scalp with AGA through RNA-seq analysis. RNA was isolated from the adipose tissues derived from the bald (frontal) and normal (occipital) scalps of male patients with AGA ( n = 4). The pooled RNA extracts from these samples were subjected to RNA sequencing, followed by differential gene expression and pathway analysis. Our gene expression analysis identified 1,060 differentially expressed genes, including 522 upregulated and 538 downregulated genes in the bald AGA scalp. Biological pathways pertaining to either adipose tissue metabolism or the hair cycle were generated in our pathway analysis. Downregulation of the peroxisome proliferator-activated receptor (PPAR) signaling pathway was noted to be significant in the bald scalp. Expression of adipogenic markers (e.g., PPARG, FABP4, PLN1 , and ADIPOQ ) was also decreased in the bald site. These findings imply that adipogenesis becomes downregulated in AGA, specifically within the bald scalp adipose. Our results lead to the hypothesis that PPARγ-mediated adipogenesis in the scalp adipose, via crosstalk with signaling pathways involved in hair cycling, might play a role in AGA. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Cruz, Hong, Aala, Tsai, Chung, Tsai, Hsu and Yang.)
Databáze:	MEDLINE
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