Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal reward contingency signals during rule-reversal.

Autor:	Trejo DH; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Ciuparu A; Transylvanian Institute of Neuroscience, Cluj-Napoca, Romania., da Silva PG; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.; current address - Champalimaud Neuroscience Program, Lisbon, Portugal., Velasquez CM; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.; current address - University of Oxford, UK., Rebouillat B; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.; current address -École Normale Supérieure, Paris, France., Gross MD; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Davis MB; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Muresan RC; Transylvanian Institute of Neuroscience, Cluj-Napoca, Romania.; STAR-UBB Institute, Babeş-Bolyai University, Cluj-Napoca, Romania., Albeanu DF; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.; School for Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2023 Sep 13. Date of Electronic Publication: 2023 Sep 13.
DOI:	10.1101/2023.09.12.557267
Abstrakt:	While animals readily adjust their behavior to adapt to relevant changes in the environment, the neural pathways enabling these changes remain largely unknown. Here, using multiphoton imaging, we investigated whether feedback from the piriform cortex to the olfactory bulb supports such behavioral flexibility. To this end, we engaged head-fixed mice in a multimodal rule-reversal task guided by olfactory and auditory cues. Both odor and, surprisingly, the sound cues triggered cortical bulbar feedback responses which preceded the behavioral report. Responses to the same sensory cue were strongly modulated upon changes in stimulus-reward contingency (rule reversals). The re-shaping of individual bouton responses occurred within seconds of the rule-reversal events and was correlated with changes in the behavior. Optogenetic perturbation of cortical feedback within the bulb disrupted the behavioral performance. Our results indicate that the piriform-to-olfactory bulb feedback carries reward contingency signals and is rapidly re-formatted according to changes in the behavioral context. Competing Interests: Declaration of interests: The authors declare no competing interests.
Databáze:	MEDLINE
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