| Autor: |
Nieto C; Department of Physics, Universidad de los Andes, Bogotá, Colombia.; Department of Electrical and Computing Engineering, University of Delaware. Newark, DE 19716, USA., Vargas-García C; AGROSAVIA Corporación Colombiana de Investigación Agropecuaria. Mosquera. Colombia., Pedraza JM; Department of Physics, Universidad de los Andes, Bogotá, Colombia., Singh A; Department of Electrical and Computing Engineering, University of Delaware. Newark, DE 19716, USA. |
| Jazyk: |
angličtina |
| Zdroj: |
BioRxiv : the preprint server for biology [bioRxiv] 2023 Sep 15. Date of Electronic Publication: 2023 Sep 15. |
| DOI: |
10.1101/2023.09.11.557238 |
| Abstrakt: |
Under ideal conditions, Escherichia coli cells divide after adding a fixed cell size, a strategy known as the adder . This concept applies to various microbes and is often explained as the division that occurs after a certain number of stages, associated with the accumulation of precursor proteins at a rate proportional to cell size. However, under poor media conditions, E. coli cells exhibit a different size regulation. They are smaller and follow a sizer-like division strategy where the added size is inversely proportional to the size at birth. We explore three potential causes for this deviation: precursor protein degradation, nonlinear accumulation rate, and a threshold size termed the commitment size . These models fit mean trends but predict different distributions given the birth size. To validate these models, we used the Akaike information criterion and compared them to open datasets of slow-growing E. coli cells in different media. the degradation model could explain the division strategy for media where cells are larger, while the commitment size model could account for smaller cells. The power-law model, finally, better fits the data at intermediate regimes. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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