Genetic Variants That Modify the Neuroendocrine Regulation of Foraging Behavior in C. elegans .

Autor:	Lee H; Division of Infectious Diseases, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School; Boston, 02115, USA., Boor SA; Division of Infectious Diseases, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School; Boston, 02115, USA.; Department of Biology, Massachusetts Institute of Technology; Cambridge, 02139, USA., Hilbert ZA; Department of Biology, Massachusetts Institute of Technology; Cambridge, 02139, USA., Meisel JD; Department of Biology, Massachusetts Institute of Technology; Cambridge, 02139, USA., Park J; Division of Infectious Diseases, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School; Boston, 02115, USA., Wang Y; Department of Molecular Biosciences, Northwestern University; Evanston, 60208, USA., McKeown R; Department of Molecular Biosciences, Northwestern University; Evanston, 60208, USA., Fischer SEJ; Division of Infectious Diseases, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School; Boston, 02115, USA., Andersen EC; Department of Molecular Biosciences, Northwestern University; Evanston, 60208, USA., Kim DH; Division of Infectious Diseases, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School; Boston, 02115, USA.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2023 Sep 19. Date of Electronic Publication: 2023 Sep 19.
DOI:	10.1101/2023.09.09.556976
Abstrakt:	The molecular mechanisms underlying diversity in animal behavior are not well understood. A major experimental challenge is determining the contribution of genetic variants that affect neuronal gene expression to differences in behavioral traits. The neuroendocrine TGF-beta ligand, DAF-7, regulates diverse behavioral responses of Caenorhabditis elegans to bacterial food and pathogens. The dynamic neuron-specific expression of daf-7 is modulated by environmental and endogenous bacteria-derived cues. Here, we investigated natural variation in the expression of daf-7 from the ASJ pair of chemosensory neurons and identified common variants in gap-2 , encoding a GTPase-Activating Protein homologous to mammalian SynGAP proteins, which modify daf-7 expression cell-non-autonomously and promote exploratory foraging behavior in a DAF-7-dependent manner. Our data connect natural variation in neuron-specific gene expression to differences in behavior and suggest that genetic variation in neuroendocrine signaling pathways mediating host-microbe interactions may give rise to diversity in animal behavior. Competing Interests: Competing interests: Authors declare that they have no competing interests.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu