Herpes simplex Virus Pneumonitis in an Acute/Subacute Paracoccidioidomycosis Patient With Malabsorption Syndrome. Case-Report and Literature Review.

Autor:	Cavalcante RS; Tropical Diseases Area, School of Medicine, São Paulo State University-UNESP, Botucatu, Brazil., Souza BS; Tropical Diseases Area, School of Medicine, São Paulo State University-UNESP, Botucatu, Brazil., Duarte IX; Department of Pathology, School of Medicine, São Paulo State University-UNESP, Botucatu, Brazil., Moraes MPT; Department of Pathology, School of Medicine, São Paulo State University-UNESP, Botucatu, Brazil., Coelho KIR; Department of Pathology, School of Medicine, São Paulo State University-UNESP, Botucatu, Brazil., Griva BL; Nuclear Medicine Service, School of Medicine, São Paulo State University-UNESP, Botucatu, Brazil., Pereira BAS; Tropical Diseases Area, School of Medicine, São Paulo State University-UNESP, Botucatu, Brazil., Calvi SA; Tropical Diseases Area, School of Medicine, São Paulo State University-UNESP, Botucatu, Brazil., Betini M; University Library, São Paulo State University-UNESP, Botucatu, Brazil., Mendes RP; Tropical Diseases Area, School of Medicine, São Paulo State University-UNESP, Botucatu, Brazil.
Jazyk:	angličtina
Zdroj:	Frontiers in fungal biology [Front Fungal Biol] 2022 Feb 10; Vol. 2, pp. 805502. Date of Electronic Publication: 2022 Feb 10 (Print Publication: 2021).
DOI:	10.3389/ffunb.2021.805502
Abstrakt:	Paracoccidioides sp.- Herpes simplex virus (HSV) co-infection was not reported until now and malabsorption syndrome is a rare complication of the acute/subacute form (AF) of paracoccidioidomycosis (PCM), characterized by life-threatening abnormalities, such as fat and protein loss, lymphopenia, ascites, and intense immunosuppression. A 21-year-old woman presented the PCM AF with intense involvement of the abdominal and intestinal lymphoid organs, which leads to the malabsorption syndrome and severe immunosuppression. This patient developed a fatal-disseminated HSV infection associated with the paracoccidioidal disease. This case demonstrates that, in addition to the antigen-specific immunosuppression, some PCM patients can present a generalized cell-mediated immune depression and endogenous infection of latent microorganisms. On the best of our knowledge, this is the first report of an association between PCM and HSV infection. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Cavalcante, Souza, Duarte, Moraes, Coelho, Griva, Pereira, Calvi, Betini and Mendes.)
Databáze:	MEDLINE
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