Longitudinal serum neurofilament light kinetics in post-anoxic encephalopathy.

Autor: Disanto G; Neurocenter of Southern Switzerland, Civic Hospital, Ente Ospedaliero Cantonale, Lugano, Switzerland., Villa M; Department of Cardiac Anesthesia and Intensive Care, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Lugano, Switzerland., Maleska Maceski A; Department of Neurology, University Hospital and University of Basel, Basel, Switzerland.; Multiple Sclerosis Centre and Research Centre for Clinical Neurimmunology and Neuroscience (RC2NB), Departments of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland., Prosperetti C; Neurocenter of Southern Switzerland, Civic Hospital, Ente Ospedaliero Cantonale, Lugano, Switzerland., Gobbi C; Neurocenter of Southern Switzerland, Civic Hospital, Ente Ospedaliero Cantonale, Lugano, Switzerland., Kuhle J; Department of Neurology, University Hospital and University of Basel, Basel, Switzerland.; Multiple Sclerosis Centre and Research Centre for Clinical Neurimmunology and Neuroscience (RC2NB), Departments of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland., Cassina T; Department of Cardiac Anesthesia and Intensive Care, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Lugano, Switzerland., Agazzi P; Neurocenter of Southern Switzerland, Civic Hospital, Ente Ospedaliero Cantonale, Lugano, Switzerland.
Jazyk: angličtina
Zdroj: Annals of clinical and translational neurology [Ann Clin Transl Neurol] 2023 Dec; Vol. 10 (12), pp. 2407-2412. Date of Electronic Publication: 2023 Sep 25.
DOI: 10.1002/acn3.51903
Abstrakt: Serum neurofilament light (sNfL) is a promising marker of outcome after cardiac arrest, but its kinetics are unclear. We prospectively measured sNfL concentrations in 62 patients at 0, 1, 3, 5, 7 and 10 days after cardiac arrest. Survivors and non-survivors had similar sNfL at admission (14.2 [8.6-21.9] vs. 22.5 [14.2-46.9] pg/mL) but largely different at 24 h (16.4 [10.2-293] vs. 464.3 [151.8-1658.2], respectively). The AUC for sNfL concentrations predicting death was above 0.95 from Day 1 to 10 (highest on Day 3). Late sNfL measurements may exert prognostic value, especially when early samples are unavailable or prognosis remains unclear.
(© 2023 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.)
Databáze: MEDLINE
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