Does it work in childhood and adolescence? The predictive role of postoperative/preablative stimulated thyroglobulin levels in paediatric thyroid cancer. A systematic review of the literature.

Autor: Piccardo A; Department of Nuclear Medicine, E.O. 'Ospedali Galliera', Genoa, 16128, Italy. Arnoldo.piccardo@galliera.it.; Centro della Tiroide, E.O. 'Ospedali Galliera', Genoa, Italy. Arnoldo.piccardo@galliera.it., Fiz F; Department of Nuclear Medicine, E.O. 'Ospedali Galliera', Genoa, 16128, Italy.; Centro della Tiroide, E.O. 'Ospedali Galliera', Genoa, Italy., Bottoni G; Department of Nuclear Medicine, E.O. 'Ospedali Galliera', Genoa, 16128, Italy.; Centro della Tiroide, E.O. 'Ospedali Galliera', Genoa, Italy., Foppiani L; Centro della Tiroide, E.O. 'Ospedali Galliera', Genoa, Italy.; Department of Internal Medicine, E.O. 'Ospedali Galliera', Genoa, Italy., Albano D; Nuclear Medicine Department, University of Brescia and ASST Spedali Civili Di Brescia, P.le Spedali Civili 1, Brescia, 25123, Italy., Bertagna F; Nuclear Medicine Department, University of Brescia and ASST Spedali Civili Di Brescia, P.le Spedali Civili 1, Brescia, 25123, Italy., Catrambone U; Centro della Tiroide, E.O. 'Ospedali Galliera', Genoa, Italy.; Department of General and Endocrine Surgery, 'Ospedali Galliera', Genoa, Italy., Mariani F; Centro della Tiroide, E.O. 'Ospedali Galliera', Genoa, Italy.; Department of General and Endocrine Surgery, 'Ospedali Galliera', Genoa, Italy., Sambucco B; Department of Nuclear Medicine, E.O. 'Ospedali Galliera', Genoa, 16128, Italy.; Centro della Tiroide, E.O. 'Ospedali Galliera', Genoa, Italy., Massollo M; Department of Nuclear Medicine, E.O. 'Ospedali Galliera', Genoa, 16128, Italy.; Centro della Tiroide, E.O. 'Ospedali Galliera', Genoa, Italy., Treglia G; Clinic of Nuclear Medicine, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.; Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana (USI), Lugano, Switzerland., Trimboli P; Faculty of Biomedical Sciences, Università della Svizzera Italiana (USI), Lugano, Switzerland. Pierpaolo.Trimboli@eoc.ch.; Clinic of Endocrinology and Diabetology, Ente Ospedaliero Cantonale, Via Ospedale 12, Bellinzona, 6500, Switzerland. Pierpaolo.Trimboli@eoc.ch.
Jazyk: angličtina
Zdroj: Reviews in endocrine & metabolic disorders [Rev Endocr Metab Disord] 2024 Feb; Vol. 25 (1), pp. 53-63. Date of Electronic Publication: 2023 Sep 25.
DOI: 10.1007/s11154-023-09835-z
Abstrakt: Background: Thyroglobulin is a well-established disease marker during follow-up in paediatric differentiated thyroid cancer. However, no conclusive data on the role of endogenously stimulated thyroglobulin after thyroidectomy (ptTg) in predicting disease-specific outcomes are available. This review aims to establish the prognostic value of ptTg in children with DTC.
Methods: Online medical databases were searched for studies evaluating the association between ptTg and disease-specific outcomes in DTC-affected children. Documents not in English, preclinical studies, other review articles, case reports, and small case series were excluded. The risk of bias was assessed with the QUADAS-2 tool.
Results: Twelve studies, analysing 1043 children in total, were included in the review. They all had a retrospective design and were published between 2016 and 2022. Of all patients, 1008 (97%) and 849 (81%) had undergone thyroidectomy and RAI, respectively. Eight studies (756 children) evaluated the correlation between ptTg and disease persistence/relapse: six reported a significant association between these parameters; a specific ptTg cut-off (10-14 ng/ml) was identified at the multivariate analysis in three studies. The remaining four studies assessed the link between ptTg levels and disease extension, with three reporting a correlation between ptTg and lung/nodal metastases.
Discussion: ptTg is a readily available and inexpensive parameter, bearing a strong prognostic power in identifying disease persistence, relapse, and the presence of metastases in children affected by DTC.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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