Ultrastructural evidence of telocytes in the embryonic chick heart.

Autor: Junatas KL; Department of Morphology, Medical Imaging, Orthopaedics, Physiotherapy and Nutrition - Laboratory of Morphology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.; Department of Basic Veterinary Sciences, College of Veterinary Medicine, University of Southern Mindanao, Cotabato, Philippines., Couck L; Department of Morphology, Medical Imaging, Orthopaedics, Physiotherapy and Nutrition - Laboratory of Morphology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium., Tay H; Department of Morphology, Medical Imaging, Orthopaedics, Physiotherapy and Nutrition - Laboratory of Morphology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium., Sinowatz F; Institute of Anatomy, Histology and Embryology, Department of Veterinary Sciences, Ludwig-Maximilians-University of Munich, Munich, Germany., Van Den Broeck W; Department of Morphology, Medical Imaging, Orthopaedics, Physiotherapy and Nutrition - Laboratory of Morphology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Jazyk: angličtina
Zdroj: Anatomia, histologia, embryologia [Anat Histol Embryol] 2024 Jan; Vol. 53 (1), pp. e12970. Date of Electronic Publication: 2023 Sep 23.
DOI: 10.1111/ahe.12970
Abstrakt: The cardiac telocyte (TC) is a novel interstitial cell type with a unique ultrastructure and great potential in therapy. The present study examined its presence in the heart of chicken embryos ageing 7-15 days old (Hamburger-Hamilton [HH] stages 31-41) using transmission electron microscopy. TCs were identified across all stages in the atrial and ventricular myocardium, close to maturing cardiomyocytes, blood vessels and lymphatics. Early-stage TCs have immature features resembling mesenchymal cells. Late-stage TCs were distinct, possessing the cytoplasmic prolongations termed telopodes (Tps), which are very long and thin, usually 1-3 in number, and display a moniliform appearance and have an average thickness below 0.2 μm. TCs residing in the epicardium and endocardium were also detected. In the subepicardium near developing coronary vessels, they were localized in the cardiac stem cell niches, coexisting with cardiac stem cells and cardiomyocyte progenitors. Electron-dense structures and the release of extracellular vesicles were observed between embryonic TCs and surrounding structures, suggesting roles in intercellular communication, cardiomyocyte differentiation and maturation, angiogenesis, and stem cell nursing and guidance.
(© 2023 Wiley-VCH GmbH. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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