| Autor: |
Mamadalieva R; Kokand State Pedagogical Institute, Kokand, Uzbekistan., Xujayev V; Kokand State Pedagogical Institute, Kokand, Uzbekistan., Sharopov FS; Research Institution 'Chinese-Tajik Innovation Center for Natural Products,' National Academy of Sciences of Tajikistan, Dushanbe, Tajikistan., Wink M; Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Heidelberg, Germany. |
| Jazyk: |
angličtina |
| Zdroj: |
Natural product research [Nat Prod Res] 2024 Nov; Vol. 38 (21), pp. 3818-3822. Date of Electronic Publication: 2023 Sep 23. |
| DOI: |
10.1080/14786419.2023.2260068 |
| Abstrakt: |
A crude methanol extract of the roots of Allochrusa gypsophiloides (syn. Acanthophyllum gypsophiloides ) (collected from the Tashkent region of Uzbekistan) was chemically characterised by UHPLC-ESI-QTOF-MS/MS analysis. The results indicate the presence of six major bisdesmosidic saponins derived from gypsogenin, gypsogenic and quillaic acids, including five compounds reported for the first time for this species. The chloroform, methanol and water extracts of A. gypsophiloides showed weak antioxidant and anthelmintic activities. Among the tested extracts, the water extract exhibited the highest level of cytotoxicity in CCRF-CEM and CEM/ADR5000 cell lines with IC50 values of 23.6 and 31.9 µg/mL, respectively. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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