Progress and emerging strategies to preserve function in the treatment of sinonasal cancer.

Autor: Robbins KT; Department of Otolaryngology - Head and Neck Surgery, School of Medicine, Southern Illinois University, Springfield, Illinois, USA., Ronen O; Department of Otolaryngology - Head and Neck Surgery, Galilee Medical Center, Affiliated with Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel., Saba NF; Department of Hematology and Medical Oncology, The Winship Cancer Institute of Emory University, Atlanta, Georgia, USA., Strojan P; Department of Radiation Oncology, Institute of Oncology, Ljubljana, Slovenia., Vander Poorten V; Otorhinolaryngology - Head and Neck Surgery and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.; Department of Oncology, Section of Head and Neck Oncology, KU Leuven, Leuven, Belgium., Mäkitie A; Department of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.; Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland., López F; Department of Otolaryngology, Hospital Universitario Central de Asturias, University of Oviedo, ISPA, IUOPA, CIBERONC, Oviedo, Spain., Rodrigo JP; Department of Otolaryngology, Hospital Universitario Central de Asturias, University of Oviedo, ISPA, IUOPA, CIBERONC, Oviedo, Spain., Homma A; Department of Otolaryngology - Head and Neck Surgery, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, Hokkaido, Japan., Hanna E; Department of Head & Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA., Ferlito A; International Head and Neck Scientific Group, Padua, Italy.
Jazyk: angličtina
Zdroj: Head & neck [Head Neck] 2023 Nov; Vol. 45 (11), pp. 2955-2966. Date of Electronic Publication: 2023 Sep 22.
DOI: 10.1002/hed.27510
Abstrakt: The sinonasal structures and their adjacent organs host several functions including vision, olfaction, nasal respiration and filtration, secretory immunity, facial expression, articulation, and oral deglutition. We reviewed the current evidence supporting functional preservation in sinonasal cancer treatment. Primary surgery with or without adjuvant modalities continues to be the standard of care for sinonasal cancer. Unfortunately, functional compromise remains a dominant negative feature of this approach. More recently, through advances in therapeutic techniques and improved understanding of the relevant tumor biology, treatments aimed at preserving function and cosmesis are emerging. The evidence for such progress involving minimal access surgery, surgical reconstruction for rehabilitation, new techniques in radiation therapy, inclusion of systemic and locally enhanced chemotherapy, and therapeutic agents based on molecular targets are highlighted. This multi-prong approach bodes well for future patients with sinonasal cancer to undergo successful treatment that includes maximal preservation of associated functions.
(© 2023 Wiley Periodicals LLC.)
Databáze: MEDLINE
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