Latest advances in clinical studies of circulating tumor cells in early and metastatic breast cancer.

Autor:	Munoz-Arcos LS; Department of Medicine, Division of Hematology-Oncology, Weill Cornell Medicine, New York, NY, United States., Nicolò E; Department of Medicine, Division of Hematology-Oncology, Weill Cornell Medicine, New York, NY, United States; Division of New Drugs and Early Drug Development, European Institute of Oncology IRCCS, Milan, Italy; Department of Oncology and Hematology-Oncology, University of Milan, Milan, Italy., Serafini MS; Department of Medicine, Division of Hematology-Oncology, Weill Cornell Medicine, New York, NY, United States., Gerratana L; Department of Medical Oncology, CRO Aviano, National Cancer Institute, IRCCS, Aviano, Italy., Reduzzi C; Department of Medicine, Division of Hematology-Oncology, Weill Cornell Medicine, New York, NY, United States., Cristofanilli M; Department of Medicine, Division of Hematology-Oncology, Weill Cornell Medicine, New York, NY, United States. Electronic address: mac9795@med.cornell.edu.
Jazyk:	angličtina
Zdroj:	International review of cell and molecular biology [Int Rev Cell Mol Biol] 2023; Vol. 381, pp. 1-21. Date of Electronic Publication: 2023 Sep 01.
DOI:	10.1016/bs.ircmb.2023.07.005
Abstrakt:	Circulating tumor cells (CTCs) have emerged as a promising biomarker in breast cancer, offering insights into disease progression and treatment response. While CTCs have demonstrated prognostic relevance in early breast cancer, more validation is required to establish optimal cut-off points. In metastatic breast cancer, the detection of CTCs using the Food and Drug Administration-approved CellSearch® system is a strong independent prognostic factor. However, mesenchymal CTCs and the Parsortix® PC1 system show promise as alternative detection methods. This chapter offers a comprehensive review of clinical studies on CTCs in breast cancer, emphasizing their prognostic and predictive value in different stages of the disease and provides insights into potential future directions in CTC research. (Copyright © 2023. Published by Elsevier Inc.)
Databáze:	MEDLINE
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