Un-FASN-ing cancer's seat belt: Linking lipid metabolism and antigen presentation.
| Autor: | Corey Z; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Schechter E; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Nemenoff RA; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Electronic address: raphael.nemenoff@cuanschutz.edu. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Cell chemical biology [Cell Chem Biol] 2023 Sep 21; Vol. 30 (9), pp. 1004-1006. |
| DOI: | 10.1016/j.chembiol.2023.08.013 |
| Abstrakt: | MHC-II expression on cancer cells is associated with improved treatment outcome. In this issue, Huang et al. 1 report a panel of small molecules that selectively upregulate MHC-II on cancer cells through suppression of fatty acid synthase (FASN), resulting in inhibition of tumor growth. Targeting this link between lipid metabolism and antigen presentation may improve response to immunotherapy. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2023 Elsevier Ltd. All rights reserved.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|