Successful treatment with streptomycin of genital leptospirosis in naturally infected cows under field conditions.

Autor: Aymée L; Laboratory of Veterinary Bacteriology, Biomedical Institute, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil., Di Azevedo MIN; Laboratory of Veterinary Bacteriology, Biomedical Institute, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil., Gregg W; Laboratory of Veterinary Bacteriology, Biomedical Institute, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil., Ezepha C; Laboratory of Veterinary Bacteriology, Biomedical Institute, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil., Carvalho-Costa FA; Laboratory of Epidemiology and Molecular Systematics, Oswaldo Cruz Institute, Rio de Janeiro, Brazil., Lilenbaum W; Laboratory of Veterinary Bacteriology, Biomedical Institute, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil. Electronic address: wlilenbaum@id.uff.br.
Jazyk: angličtina
Zdroj: Research in veterinary science [Res Vet Sci] 2023 Nov; Vol. 164, pp. 105020. Date of Electronic Publication: 2023 Sep 17.
DOI: 10.1016/j.rvsc.2023.105020
Abstrakt: The single-dose protocol of streptomycin treatment has been recommended to treat renal leptospirosis in bovines. However, treating genital infection remains a challenge. Recently, a protocol using three doses of streptomycin demonstrated effectiveness in the genital clearance of experimentally infected ewes. Therefore, the present study aimed to apply this three-dose protocol for genital infection treatment in naturally infected cows under field conditions. Thirty beef cows were diagnosed as positive by lipL32-PCR in their genital samples. Nucleotide sequences (n = 10) characterized them as Leptospira interrogans sg Sejroe, genetically related to Hardjoprajitno strains. After molecular diagnosis, 13 cows received a single dose of 25 mg/kg streptomycin. The other 17 cows were submitted to the three-dose protocol. The successful treatment rate of genital infection on the single streptomycin dose was 7/13 (53.8%), while the cows that received the three doses 16/17 were negative (94.1% of efficacy). Based on those results, we conclude that the standard treatment preconized for renal infection is not adequate for genital infection, and the three-dose protocol was successful in eliminating the carrier status of genital leptospirosis.
Competing Interests: Declaration of Competing Interest We have no conflict of interest to declare.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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