| Autor: |
Krukiewicz K; Department of Physical Chemistry and Technology of Polymers, Silesian University of Technology, 44-100 Gliwice, Poland.; Centre for Organic and Nanohybrid Electronics, Silesian University of Technology, 44-100 Gliwice, Poland., Czerwińska-Główka D; Department of Physical Chemistry and Technology of Polymers, Silesian University of Technology, 44-100 Gliwice, Poland., Turczyn RM; Department of Physical Chemistry and Technology of Polymers, Silesian University of Technology, 44-100 Gliwice, Poland.; Centre for Organic and Nanohybrid Electronics, Silesian University of Technology, 44-100 Gliwice, Poland., Blacha-Grzechnik A; Department of Physical Chemistry and Technology of Polymers, Silesian University of Technology, 44-100 Gliwice, Poland.; Centre for Organic and Nanohybrid Electronics, Silesian University of Technology, 44-100 Gliwice, Poland., Vallejo-Giraldo C; Centre for Research in Medical Devices, University of Galway, H91 TK33 Galway, Ireland., Erfurt K; Department of Chemical Organic Technology and Petrochemistry, Silesian University of Technology, 44-100 Gliwice, Poland., Chrobok A; Department of Chemical Organic Technology and Petrochemistry, Silesian University of Technology, 44-100 Gliwice, Poland., Faure-Vincent J; CEA/INAC/SPrAM, Laboratoire d'Electronique Moléculaire Organique et Hybride, 38000 Grenoble, France., Pouget S; CEA/INAC/SPrAM, Laboratoire d'Electronique Moléculaire Organique et Hybride, 38000 Grenoble, France., Djurado D; CEA/INAC/SPrAM, Laboratoire d'Electronique Moléculaire Organique et Hybride, 38000 Grenoble, France., Biggs MJP; Centre for Research in Medical Devices, University of Galway, H91 TK33 Galway, Ireland. |
| Abstrakt: |
Electrical stimulation has been used successfully for several decades for the treatment of neurodegenerative disorders, including motor disorders, pain, and psychiatric disorders. These technologies typically rely on the modulation of neural activity through the focused delivery of electrical pulses. Recent research, however, has shown that electrically triggered neuromodulation can be further enhanced when coupled with optical stimulation, an approach that can benefit from the development of novel electrode materials that combine transparency with excellent electrochemical and biological performance. In this study, we describe an electrochemically modified, nanostructured indium tin oxide/poly(ethylene terephthalate) (ITO/PET) surface as a flexible, transparent, and cytocompatible electrode material. Electrochemical oxidation and reduction of ITO/PET electrodes in the presence of an ionic liquid based on d-glucopyranoside and bistriflamide units were performed, and the electrochemical behavior, conductivity, capacitance, charge transport processes, surface morphology, optical properties, and cytocompatibility were assessed in vitro. It has been shown that under selected conditions, electrochemically modified ITO/PET films remained transparent and highly conductive and were able to enhance neural cell survival and neurite outgrowth. Consequently, electrochemical modification of ITO/PET electrodes in the presence of an ionic liquid is introduced as an effective approach for tailoring the properties of ITO for advanced bio-optoelectronic applications. |
