Abdominal adipose tissue distribution assessed by computed tomography and mortality in hospitalised patients with COVID-19: a retrospective longitudinal cohort study.

Autor: Battisti S; Radiology Department, AUSL Romagna M. Bufalini Hospital, Cesena, Italy.; Radiology Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy.; Department of Experimental, Diagnostic and Specialty Medicine - DIMES, Alma Mater Studiorum-Università di Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy., Pedone C; Department of Medicine and Surgery, Research Unit of Geriatrics, Università Campus Bio-Medico di Roma, Rome, Italy.; Fondazione Policlinico Universitario Campus Bio-Medico, Operative Research Unit of Geriatrics, Rome, Italy., Tramontana F; Department of Medicine and Surgery, Research Unit of Endocrinology & Diabetes, Università Campus Bio-Medico di Roma, Rome, Italy., Napoli N; Department of Medicine and Surgery, Research Unit of Endocrinology & Diabetes, Università Campus Bio-Medico di Roma, Rome, Italy.; Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy., Alhamar G; Department of Medicine and Surgery, Research Unit of Endocrinology & Diabetes, Università Campus Bio-Medico di Roma, Rome, Italy., Russo E; Anesthesia and Intensive Care Unit, AUSL Romagna, M.Bufalini Hospital, Cesena, Italy., Agnoletti V; Anesthesia and Intensive Care Unit, AUSL Romagna, M.Bufalini Hospital, Cesena, Italy., Paolucci E; Internal Medicine Unit, AUSL Romagna, M.Bufalini Hospital, Cesena, Italy., Galgani M; Department of Molecular Medicine and Medical Biotechnology, University of Naples 'Federico II', Naples, Italy.; Institute for Endocrinology and Experimental Oncology 'G. Salvatore', Consiglio Nazionale delle Ricerche (C.N.R.), Naples, Italy., Giampalma E; Radiology Department, AUSL Romagna M. Bufalini Hospital, Cesena, Italy., Paviglianiti A; Department of Medicine and Surgery, Research Unit of Endocrinology & Diabetes, Università Campus Bio-Medico di Roma, Rome, Italy.; Clinical Hematology Department, Institut Català d'Oncologia-Hospitalet, 08908, Barcelona, Spain.; Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), 08908, Barcelona, Spain., Strollo R; Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open University, Rome, Italy. rocky.strollo@uniroma5.it.
Jazyk: angličtina
Zdroj: Endocrine [Endocrine] 2024 Mar; Vol. 83 (3), pp. 597-603. Date of Electronic Publication: 2023 Sep 22.
DOI: 10.1007/s12020-023-03530-4
Abstrakt: Background: Visceral adiposity has been associated with an increased risk of critical illness in COVID-19 patients. However, if it also associates to a poor survival is still not well established. The aim of the study was to assess the relationship between abdominal fat distribution and COVID-19 mortality.
Methods: In this six-month longitudinal cohort study, abdominal visceral (VAT) and subcutaneous adipose tissues (SAT) were measured by computed tomography in a cohort of 174 patients admitted to the emergency department with a diagnosis of COVID-19, during the first wave of pandemic. The primary exposure and outcome measures were VAT and SAT at hospital admission, and death at 30 and 180 days, respectively.
Results: Overall survival was not different according to VAT (p = 0.94), SAT (p = 0.32) and VAT/SAT ratio (p = 0.64). However, patients in the lowest SAT quartile (thickness ≤ 11.25 mm) had a significantly reduced survival compared to those with thicker SAT (77 vs. 94% at day 30; 74 vs. 91% at day 180, p = 0.01). Similarly, a thinner SAT was associated with lower survival in Intensive Care Unit (ICU) admitted patients, independently of sex or age (p = 0.02). The VAT/SAT ratio showed a non-linear increased risk of ICU admission, which plateaued out and tended for inversion at values greater than 1.9 (p = 0.001), although was not associated with increased mortality rate.
Conclusions: In our cohort, visceral adiposity did not increase mortality in patients with COVID-19, but low SAT may be associated with poor survival.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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