Digestive Tolerance and Safety of an Anti-Regurgitation Formula Containing Locust Bean Gum, Prebiotics and Postbiotics: A Real-World Study.
| Autor: | Bellaiche M; Department of Gastroenterology and Pediatric Nutrition, Hospital Robert-Debré, AP-HP, Paris, France., Tounian P; Department of Pediatric Nutrition and Gastroenterology, Trousseau Hospital, AP-HP, Sorbonne Université, Paris, France., Oozeer R; Danone Nutricia Research, Utrecht, Netherlands., Rocher E; Danone Nutricia Research, Utrecht, Netherlands., Vandenplas Y; KidZ Health Castle, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium. |
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| Jazyk: | angličtina |
| Zdroj: | Pediatric gastroenterology, hepatology & nutrition [Pediatr Gastroenterol Hepatol Nutr] 2023 Sep; Vol. 26 (5), pp. 249-265. Date of Electronic Publication: 2023 Sep 01. |
| DOI: | 10.5223/pghn.2023.26.5.249 |
| Abstrakt: | Purpose: Infant regurgitation is associated with other functional gastrointestinal disorders and signs and symptoms that have a major impact on the quality of life of infants and their families. This study evaluated the safety, tolerance, and real-world effectiveness of an anti-regurgitation formula containing locust bean gum (LBG), prebiotics, and postbiotics to alleviate digestive symptoms beyond regurgitation. Methods: This 3-month study involved infants with regurgitation requiring the prescription of an anti-regurgitation formula according to usual clinical practice. Outcomes included evaluation of the evolution of stool consistency and frequency; occurrence of colic, constipation, and diarrhea; and assessment of regurgitation severity. Infant crying, parental assessment of infant well-being, and parental satisfaction with the stool consistency were also evaluated. Results: In total, 190 infants (average age: 1.9±1.1 months) were included. After three months, stool frequency and consistency remained within the normal physiological range, with 82.7% of infants passing one or two stools per day and 90.4% passing loose or formed stools. There was no significant increase in the number of infants with diarrhea, whereas a decrease was observed in the number of infants with constipation after 1 month ( p =0.001) and with colic after both 1 and 3 months ( p <0.001). Regurgitation severity and crying decreased and parental satisfaction with stool consistency, formula acceptability, infant well-being, and sleep quality increased. Monitoring of adverse events did not reveal any safety concerns. Conclusion: Formulas containing LBG, prebiotics, and postbiotics were well tolerated and provided an effective strategy for managing infant regurgitation and gastrointestinal discomfort. Competing Interests: Conflict of Interest: Raish Oozeer and Emilie Rocher are employees of Danone Nutricia Research. Marc Bellaiche, Patrick Tounian, and Yvan Vandenplas received fees for participating in the scientific committee of the study. (Copyright © 2023 by The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition.) |
| Databáze: | MEDLINE |
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