Importance of PET/CT in Initial Workup of Head and Neck Squamous Cell Carcinoma.

Autor: Hellums RN; Department of Otolaryngology-Head and Neck Surgery Facial Plastic Surgery Geisinger Medical Center Danville Pennsylvania USA., Pichardo PFA; Department of Otolaryngology-Head and Neck Surgery Facial Plastic Surgery Geisinger Medical Center Danville Pennsylvania USA., Altman KW; Department of Otolaryngology-Head and Neck Surgery Facial Plastic Surgery Geisinger Medical Center Danville Pennsylvania USA., Penn E; Doctor of Medicine Program Geisinger Commonwealth School of Medicine Scranton Pennsylvania USA., Stavrides KP; Department of Otolaryngology-Head and Neck Surgery Facial Plastic Surgery Geisinger Medical Center Danville Pennsylvania USA., Purdy NC; Department of Otolaryngology-Head and Neck Surgery Facial Plastic Surgery Geisinger Medical Center Danville Pennsylvania USA.
Jazyk: angličtina
Zdroj: OTO open [OTO Open] 2023 Sep 20; Vol. 7 (3), pp. e75. Date of Electronic Publication: 2023 Sep 20 (Print Publication: 2023).
DOI: 10.1002/oto2.75
Abstrakt: Objective: Assess the impact of positron emission tomography/computed tomography (PET/CT) on disease staging at presentation in patients with head and neck squamous cell carcinoma.
Study Design: Retrospective cross-sectional review.
Setting: Academic multicenter single institution (Geisinger Health System).
Methods: All patients who had PET/CT imaging during workup for head and neck squamous cell carcinoma were included in the study. Pre- and post-PET/CT clinical staging were recorded. Statistical analyses were performed for patients with a change in clinical staging or detection of second primary malignancies on PET/CT.
Results: A total of 292 patients were included in the study, 238 of whom underwent PET/CT imaging as part of their initial workup. Twenty-eight (11.9%) patients were clinically upstaged on PET/CT with 7 patients having treatment alterations based on imaging. Eighteen (7.6%) patients were found to have second primary malignancies on PET/CT.
Conclusion: The current study further illustrates the importance of PET/CT in the workup of head and neck squamous cell carcinoma. Without the inclusion of PET/CT imaging, 19.3% of patients would have either been staged inappropriately or had second primary malignancies missed, again confirming the necessity of comprehensive functional imaging during the initial pretreatment workup.
Competing Interests: Ryan N. Hellums, Priscilla F. A. Pichardo, Ellen Penn, Kevin P. Stavrides, Nicholas C. Purdy: None. Kenneth W. Altman: Merck (consultant, speaker, publication advisory board [uncompensated]), Vindico (CME faculty in programs sponsored by Merck), AXDEV (Marketing consultant in a program sponsored by Merck), and Bayer (confidentiality agreement, uncompensated).
(© 2023 The Authors. OTO Open published by Wiley Periodicals LLC on behalf of American Academy of Otolaryngology–Head and Neck Surgery Foundation.)
Databáze: MEDLINE
Externí odkaz: