Somatostatin neurons in prefrontal cortex initiate sleep-preparatory behavior and sleep via the preoptic and lateral hypothalamus.

Autor: Tossell K; Department of Life Sciences, Imperial College London, London, UK., Yu X; Department of Life Sciences, Imperial College London, London, UK.; Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China., Giannos P; Department of Life Sciences, Imperial College London, London, UK., Anuncibay Soto B; Department of Life Sciences, Imperial College London, London, UK.; UK Dementia Research Institute, Imperial College London, London, UK., Nollet M; Department of Life Sciences, Imperial College London, London, UK.; UK Dementia Research Institute, Imperial College London, London, UK., Yustos R; Department of Life Sciences, Imperial College London, London, UK., Miracca G; Department of Life Sciences, Imperial College London, London, UK., Vicente M; Department of Life Sciences, Imperial College London, London, UK., Miao A; Department of Life Sciences, Imperial College London, London, UK.; UK Dementia Research Institute, Imperial College London, London, UK., Hsieh B; Department of Life Sciences, Imperial College London, London, UK.; Department of Electrical and Electronic Engineering, Imperial College London, London, UK.; Center for Neurotechnology, Imperial College London, London, UK., Ma Y; Department of Life Sciences, Imperial College London, London, UK., Vyssotski AL; Institute of Neuroinformatics, University of Zürich-ETH Zürich, Zürich, Switzerland., Constandinou T; Department of Electrical and Electronic Engineering, Imperial College London, London, UK.; Center for Neurotechnology, Imperial College London, London, UK.; Care Research and Technology Centre, UK Dementia Research Institute, London, UK., Franks NP; Department of Life Sciences, Imperial College London, London, UK. n.franks@imperial.ac.uk.; UK Dementia Research Institute, Imperial College London, London, UK. n.franks@imperial.ac.uk.; Center for Neurotechnology, Imperial College London, London, UK. n.franks@imperial.ac.uk., Wisden W; Department of Life Sciences, Imperial College London, London, UK. w.wisden@imperial.ac.uk.; UK Dementia Research Institute, Imperial College London, London, UK. w.wisden@imperial.ac.uk.; Center for Neurotechnology, Imperial College London, London, UK. w.wisden@imperial.ac.uk.
Jazyk: angličtina
Zdroj: Nature neuroscience [Nat Neurosci] 2023 Oct; Vol. 26 (10), pp. 1805-1819. Date of Electronic Publication: 2023 Sep 21.
DOI: 10.1038/s41593-023-01430-4
Abstrakt: The prefrontal cortex (PFC) enables mammals to respond to situations, including internal states, with appropriate actions. One such internal state could be 'tiredness'. Here, using activity tagging in the mouse PFC, we identified particularly excitable, fast-spiking, somatostatin-expressing, γ-aminobutyric acid (GABA) (PFC Sst-GABA ) cells that responded to sleep deprivation. These cells projected to the lateral preoptic (LPO) hypothalamus and the lateral hypothalamus (LH). Stimulating PFC Sst-GABA terminals in the LPO hypothalamus caused sleep-preparatory behavior (nesting, elevated theta power and elevated temperature), and stimulating PFC Sst-GABA terminals in the LH mimicked recovery sleep (non-rapid eye-movement sleep with higher delta power and lower body temperature). PFC Sst-GABA terminals had enhanced activity during nesting and sleep, inducing inhibitory postsynaptic currents on diverse cells in the LPO hypothalamus and the LH. The PFC also might feature in deciding sleep location in the absence of excessive fatigue. These findings suggest that the PFC instructs the hypothalamus to ensure that optimal sleep takes place in a suitable place.
(© 2023. The Author(s).)
Databáze: MEDLINE
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