Oral supplementation with fish cartilage hydrolysate in an adult population suffering from knee pain and function discomfort: results from an innovative approach combining an exploratory clinical study and an ex vivo clinical investigation.

Autor: Yves H; Service de Kinésithérapie et de Réadaptation Fonctionnelle, Hôpital Princesse Paola, Vivalia, Rue du Vivier 21, Marche-en-Famenne, 6900, Belgium. yhenrotin@uliege.be.; musculoSKeletal Innovative research Lab (mSKIL), University of Liège, Liège, 4000, Belgium. yhenrotin@uliege.be., Herman J; Artialis SA, Avenue de l'Hôpital 11, Liège, 4000, Belgium., Uebelhoer M; Artialis SA, Avenue de l'Hôpital 11, Liège, 4000, Belgium., Wauquier F; Clinic'n'Cell SAS, UFR de Médecine et de Pharmacie, 28 Place Henri Dunant, Clermont-Ferrand, TSA, 50400 63001, France., Boutin-Wittrant L; Clinic'n'Cell SAS, UFR de Médecine et de Pharmacie, 28 Place Henri Dunant, Clermont-Ferrand, TSA, 50400 63001, France., Donneau AF; Département des Sciences de la Santé publique, UR BSTAT ULiège, Université de Liège, Avenue Hippocrate 13, Liège, 4000, Belgium., Monseur J; Département des Sciences de la Santé publique, UR BSTAT ULiège, Université de Liège, Avenue Hippocrate 13, Liège, 4000, Belgium., Fotso VM; Artialis SA, Avenue de l'Hôpital 11, Liège, 4000, Belgium., Duquenne M; musculoSKeletal Innovative research Lab (mSKIL), University of Liège, Liège, 4000, Belgium., Wagner M; Centre Médical Chant d'oiseau, Avenue des Frères Legrain 85, Woluwe-Saint Pierre, 1150, Belgium., Bouvret E; Abyss Ingredients, 860 Route de Caudan, Caudan, 56850, France., Costes B; Artialis SA, Avenue de l'Hôpital 11, Liège, 4000, Belgium., Wittrant Y; INRAE, UNH, Clermont-Ferrand, 63001, France.; Université Clermont Auvergne, UFR de Médecine de de Pharmacie, 28 Place Henri Dunant, Clermont-Ferrand, TSA, 50400 63001, France.
Jazyk: angličtina
Zdroj: BMC musculoskeletal disorders [BMC Musculoskelet Disord] 2023 Sep 21; Vol. 24 (1), pp. 748. Date of Electronic Publication: 2023 Sep 21.
DOI: 10.1186/s12891-023-06800-4
Abstrakt: Background: Aging is frequently associated with impairments of the musculoskeletal system and many elderly people experience joint discomfort or pain which might reduce their ability to move and consequently alter their quality of life. A beneficial effect of fish cartilage hydrolysate (FCH) on pain and joint function has recently been shown in an ACLT/pMMx osteoarthritis rat model.
Methods: We therefore performed an exploratory, non-comparative, multi-centric clinical trial including 33 subjects with moderate knee joint discomfort and loss of functionality to investigate the efficacy of FCH on their algo-functional status. We further determined the potential health benefit of FCH in an original clinical ex vivo study investigating the role of FCH human metabolites on primary human chondrocytes.
Results: FCH significantly improved knee pain and function, as assessed by the Knee injury and Osteoarthritis Outcome Score (KOOS). Moreover, FCH significantly reduced pain at rest and while walking, and patient global assessment (PGA), as assessed by the Visual Analogue Scale (VAS), and improved patients' quality of life (SF-36). FCH metabolites decreased the synthesis of catabolic factors (MMP-13) and pro-inflammatory mediators (NO, PGE2) and limited the inhibitory effect of IL-1β on the synthesis of cartilage matrix components (GAG and collagen).
Conclusions: Thus, these data provide insights on the mode of action of FCH in humans and contribute to explain how FCH may relieve pain and improve joint function in subjects with knee discomfort. Although these preliminary data need to be confirmed in a randomized controlled trial, they strongly support the potential health benefit of such an active ingredient.
Trial Registration: The study was registered on clinicaltrials.gov with the identifier NCT04420091 (09/06/2020).
(© 2023. BioMed Central Ltd., part of Springer Nature.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje