Antineoplastic therapy in childhood cancer patients presents a negative impact in the periodontal tissues: a cohort study.

Autor: Longo BC; Department of Dentistry, State University of Maringá (UEM), Av. Mandacaru, 1550, Campus Universitário, Maringá, Paraná, Brazil., Rohling IB; Department of Dentistry, State University of Western Parana (UNIOESTE), Cascavel, Paraná, Brazil., Silva PLMOE; Department of Dentistry, State University of Western Parana (UNIOESTE), Cascavel, Paraná, Brazil., de Morais MEF; Department of Dentistry, State University of Maringá (UEM), Av. Mandacaru, 1550, Campus Universitário, Maringá, Paraná, Brazil., Paz HES; Department of Prosthodontics and Periodontics, Piracicaba Dental School, University of Campinas, Piracicaba, SP, Brazil., Casarin RCV; Department of Prosthodontics and Periodontics, Piracicaba Dental School, University of Campinas, Piracicaba, SP, Brazil., Nishiyama SAB; Department of Basic Health Sciences, State University of Maringá (UEM), Maringá, Paraná, Brazil., de Souza MDB; Department of Dentistry, State University of Western Parana (UNIOESTE), Cascavel, Paraná, Brazil., Silva CO; Department of Dentistry, State University of Maringá (UEM), Av. Mandacaru, 1550, Campus Universitário, Maringá, Paraná, Brazil. prof.cleversonsilva@gmail.com.
Jazyk: angličtina
Zdroj: Clinical oral investigations [Clin Oral Investig] 2023 Nov; Vol. 27 (11), pp. 6637-6644. Date of Electronic Publication: 2023 Sep 22.
DOI: 10.1007/s00784-023-05270-1
Abstrakt: Objectives: To investigate the effect of antineoplastic therapy (AT) in the periodontal tissues of childhood cancer (CC) patients.
Materials and Methods: Seventy-two individuals were divided into CC (n=36) and healthy individuals (control group-CG, n=36). Demographics, hygiene habits, CC type, and AT were collected. Salivary flow and the presence and concentration of Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Tannerella forsythia, and Fusobacterium nucleatum were analyzed. Clinical evaluation included plaque (PI) and gingival indexes (GI), periodontal probing depth (PPD), and clinical attachment level (CAL). Patients were classified into periodontal health, gingivitis, or periodontitis. Descriptive statistics, T test, Mann-Whitney test, chi-square, Fisher's exact test, and two-way analysis of variance were used (p<0.05).
Results: The mean age of the patients was similar (CC 12.0±3.9 years and CG 12.0±4.0 years). In the CC group, all patients underwent chemotherapy and nine radiotherapy. Color/race, income, and family education showed significant differences between groups. There was no difference between groups in salivary flow. Higher levels of Fusobacterium nucleatum were seen in CC (p=0.02). Significant difference between groups was found for PI (CC: 30.5%, CG: 22.6%), GI (CC: 28.8%, CG: 17.3%), PPD (CC: 1.77 mm, CG: 1.61 mm), and CAL (CC: 1.77 mm, CG: 1.57 mm), periodontal health (CC: 3, CG: 7), gingivitis (CC: 16, CG: 24), or periodontitis (CC: 17, CG: 5).
Conclusion: AT in CC patients presents a negative impact in the periodontal and microbiological parameters.
Clinical Relevance: Childhood cancer individuals showed worse periodontal parameters and higher levels of Fusobacterium nucleatum in the saliva when compared to healthy individuals.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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