Past and Future Directions for Research on Cellular Senescence.

Autor:	Zhu Y; Department of Physiology and Biomedical Engineering, Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.; Robert and Arlene Kogod Center on Aging, Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA., Anastasiadis ZP; Department of Biochemistry and Molecular Biology, Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA., Espindola Netto JM; Robert and Arlene Kogod Center on Aging, Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA., Evans T; Robert and Arlene Kogod Center on Aging, Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA., Tchkonia T; Department of Physiology and Biomedical Engineering, Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.; Robert and Arlene Kogod Center on Aging, Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA., Kirkland JL; Department of Physiology and Biomedical Engineering, Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA kirkland.james@mayo.edu.; Division of General Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.
Jazyk:	angličtina
Zdroj:	Cold Spring Harbor perspectives in medicine [Cold Spring Harb Perspect Med] 2024 Feb 01; Vol. 14 (2). Date of Electronic Publication: 2024 Feb 01.
DOI:	10.1101/cshperspect.a041205
Abstrakt:	Cellular senescence was initially described in the early 1960s by Hayflick and Moorehead. They noted sustained cell-cycle arrest after repeated subculturing of human primary cells. Over half a century later, cellular senescence has become recognized as one of the fundamental pillars of aging. Developing senotherapeutics, interventions that selectively eliminate or target senescent cells, has emerged as a key focus in health research. In this article, we note major milestones in cellular senescence research, discuss current challenges, and point to future directions for this rapidly growing field. (Copyright © 2024 Cold Spring Harbor Laboratory Press; all rights reserved.)
Databáze:	MEDLINE
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