Layered double hydroxides and their tailored hybrids/composites: Progressive trends for delivery of natural/synthetic-drug/cosmetic biomolecules.

Autor: Kumari S; Department of Chemistry, Career Point University, Tikker - Kharwarian, Hamirpur, Himachal Pradesh, 176041, India; Center for Nanoscience and Technology, Career Point University, Tikker - Kharwarian, Hamirpur, Himachal Pradesh, 176041, India., Sharma V; Department of Biotechnology & Bioinformatics, Sri Guru Gobind Singh College, Chandigarh, 160019, India., Soni S; Department of Chemistry, Career Point University, Tikker - Kharwarian, Hamirpur, Himachal Pradesh, 176041, India; Center for Nanoscience and Technology, Career Point University, Tikker - Kharwarian, Hamirpur, Himachal Pradesh, 176041, India., Sharma A; Department of Chemistry, Career Point University, Tikker - Kharwarian, Hamirpur, Himachal Pradesh, 176041, India; Center for Nanoscience and Technology, Career Point University, Tikker - Kharwarian, Hamirpur, Himachal Pradesh, 176041, India. Electronic address: ajayansu1@gmail.com., Thakur A; Department of Zoology, DAV College, Jalandhar, Punjab, 144008, India., Kumar S; Department of Food Science and Technology, Dr. YS Parmar University of Horticulture and Forestry, Nauni, Solan, Himachal Pradesh, 173230, India., Dhama K; Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, 243122, Uttar Pradesh, India., Sharma AK; Department of Biotechnology, Amity University, Sector 82 A, IT City Rd, Block D, Sahibzada Ajit Singh Nagar, Punjab, 140306, India. Electronic address: anibiotech18@gmail.com., Bhatia SK; Institute for Ubiquitous Information Technology and Applications, Konkuk University, Hwayang-dong Gwangjin-gu, Seoul, 05029, South Korea; Department of Biological Engineering, College of Engineering, Konkuk University, Hwayang-dong Gwangjin-gu, Seoul, 05029, South Korea. Electronic address: shashibiotechhpu@gmail.com.
Jazyk: angličtina
Zdroj: Environmental research [Environ Res] 2023 Dec 01; Vol. 238 (Pt 2), pp. 117171. Date of Electronic Publication: 2023 Sep 19.
DOI: 10.1016/j.envres.2023.117171
Abstrakt: Layered double hydroxides (LDHs) are well-known and important class of hydrotalcite-type anionic clays (HTs) materials that are cost-effective with additional advantages of facile synthesis, composition, tenability, and reusability. These convincing characteristics are liable for their applications in various fields related to energy, environment, catalysis, biomedical, and biotechnology. HTs/LDHs are generally synthesized from low cost abundantly available chemical precursors through the aqueous synthetic pathways under mild reaction conditions. These materials can be termed green materials based on their non-toxic nature, availability of precursors, facile and low-cost production using aqueous medium conditions with less hazardous effluents. Diverse and fascinating characteristics have been attributed to HTs/LDHs like anion exchange ability, surface basicity, biocompatibility, controlled release of the anion specific area, porosity, easy surface modification, and pH dependent biodegradability. Hence, HTs/LDHs and their modified and/or functionalized nanohybrids/nanocomposites are reported as the potential drug delivery carriers with a capability to stabilize the susceptible bioactive molecules, may enhance the solubility of poorly soluble drugs along with controlled drug/bioactive molecule release and delivery. These clay and bioactive hybrid materials have good biocompatibility, less cytotoxicity, and better site-targeting with improved cellular uptake than that of free parent biomolecules. These lamellar solids of micro/nanostructure are compatible, host-guest materials and able to fabricate with drugs/cosmeceutical/bio- or synthetic polymers without any change in their molecular structure and reactivity along with improvement in their stabilities. Other important features are facile synthesis, basicity, high stability with easy storage, and efficient administration with low bio-toxicity. This study enlightens the applications of HTs/LDHs along with their hybrids/composites in the field of drug/cosmeceutical/gene delivery systems of natural/synthetic biomolecules.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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