Magnetic xanthan gum-silk fibroin hydrogel: A nanocomposite for biological and hyperthermia applications.

Autor: Aliabadi HAM; Advanced Chemical Studies Lab, Department of Chemistry, K. N. Toosi University of Technology, Tehran, Iran., Forouzandeh-Malati M; Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran 16846-13114, Iran., Hassanzadeh-Afruzi F; Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran 16846-13114, Iran., Noruzi EB; Faculty of Chemistry, Department of Inorganic Chemistry, University of Tabriz, Tabriz, Iran., Ganjali F; Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran 16846-13114, Iran., Kashtiaray A; Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran 16846-13114, Iran., Bani MS; Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, Iran., Eftekhari RB; Department of Pharmaceuticals, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran., Eivazzadeh-Keihan R; Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran 16846-13114, Iran. Electronic address: reza.tab_chemist@yahoo.com., Maleki A; Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran 16846-13114, Iran. Electronic address: maleki@iust.ac.ir.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2023 Dec 31; Vol. 253 (Pt 4), pp. 127005. Date of Electronic Publication: 2023 Sep 19.
DOI: 10.1016/j.ijbiomac.2023.127005
Abstrakt: A magnetic xanthan hydrogel/silk fibroin nanobiocomposite (XG hydrogel/SF/Fe 3 O 4 ) was designed, fabricated, and characterized using analyzing methods such as FT-IR, EDX, FE-SEM, XRD, TGA, and VSM to evaluate the exact structure of product nanobiocomposite. The FE-SEM images reveal the presence of spherical shapes exhibiting a narrow size range and homogeneous distribution, measuring between 30 and 35 nm in diameter. The VSM analysis demonstrates the superparamagnetic properties of the XG hydrogel/SF/Fe 3 O 4 nanobiocomposite, exhibiting a magnetic saturation of 54 emu/g at room temperature. The biological response of the nanobiocomposite scaffolds was assessed through cell viability and red blood cell hemolytic assays. MCF10A cells were exposed to a concentration of 1.75 mg/mL of the nanobiocomposite, and after 2 and 3 days, the cell viability was found to be 96.95 % and 97.02 %, respectively. The hemolytic effect was nearly 0 % even at higher concentrations (2 mg/mL). Furthermore, the magnetic nanobiocomposite showed excellent potential for hyperthermia applications, with a maximum specific absorption rate of 7 W/g for 1 mg/mL of the sample under a magnetic field in different frequencies (100, 200, 300, and 400 MHz) and 5 to 20 min time intervals.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023. Published by Elsevier B.V.)
Databáze: MEDLINE
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