Daily Summer Temperatures and Hospitalization for Acute Cardiovascular Events: Impact of Outdoor PM 2.5 Oxidative Potential on Observed Associations Across Canada.

Autor:	Weichenthal S; From the Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Canada.; Air Health Science Division, Health Canada, Ottawa, Canada., Lavigne E; Environmental Health Science and Research Bureau, Health Canada, Ottawa, Canada.; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Canada., You H; Air Health Science Division, Health Canada, Ottawa, Canada., Pollitt K; Yale School of Public Health, New Haven, Connecticut., Shin T; Air Health Science Division, Health Canada, Ottawa, Canada., Kulka R; Air Health Science Division, Health Canada, Ottawa, Canada., Stieb DM; Environmental Health Science and Research Bureau, Health Canada, Ottawa, Canada., Hatzopoulou M; Department of Civil & Mineral Engineering, University of Toronto, Toronto, Ontario, Canada., Evans G; Chemical Engineering & Applied Chemistry, University of Toronto, Toronto, Ontario, Canada., Burnett RT; Environmental Health Science and Research Bureau, Health Canada, Ottawa, Canada.
Jazyk:	angličtina
Zdroj:	Epidemiology (Cambridge, Mass.) [Epidemiology] 2023 Nov 01; Vol. 34 (6), pp. 897-905. Date of Electronic Publication: 2023 Sep 26.
DOI:	10.1097/EDE.0000000000001651
Abstrakt:	Background: Oxidative stress plays an important role in the health impacts of both outdoor fine particulate air pollution (PM 2.5 ) and thermal stress. However, it is not clear how the oxidative potential of PM 2.5 may influence the acute cardiovascular effects of temperature. Methods: We conducted a case-crossover study of hospitalization for cardiovascular events in 35 cities across Canada during the summer months (July-September) between 2016 and 2018. We collected three different metrics of PM 2.5 oxidative potential each month in each location. We estimated associations between lag-0 daily temperature (per 5ºC) and hospitalization for all cardiovascular (n = 44,876) and ischemic heart disease (n = 14,034) events across strata of monthly PM 2.5 oxidative potential using conditional logistical models adjusting for potential time-varying confounders. Results: Overall, associations between lag-0 temperature and acute cardiovascular events tended to be stronger when outdoor PM 2.5 oxidative potential was higher. For example, when glutathione-related oxidative potential (OP GSH ) was in the highest tertile, the odds ratio (OR) for all cardiovascular events was 1.040 (95% confidence intervals [CI] = 1.004, 1.074) compared with 0.980 (95% CI = 0.943, 1.018) when OP GSH was in the lowest tertile. We observed a greater difference for ischemic heart disease events, particularly for older subjects (age >70 years). Conclusions: The acute cardiovascular health impacts of summer temperature variations may be greater when outdoor PM 2.5 oxidative potential is elevated. This may be particularly important for ischemic heart disease events. Competing Interests: The authors report no conflicts of interest. (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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