Acquired enamel pellicle protects gastroesophageal reflux disease patients against erosive tooth wear.

Autor: Martini T; Universidade de São Paulo - USP, Bauru School of Dentistry, Bauru, SP, Brazil., Rios D; Universidade de São Paulo - USP, Bauru School of Dentistry, Bauru, SP, Brazil., Dionizio A; Universidade de São Paulo - USP, Bauru School of Dentistry, Bauru, SP, Brazil., Cassiano LPS; Universidade de São Paulo - USP, Bauru School of Dentistry, Bauru, SP, Brazil., Silva CMSE; Universidade de São Paulo - USP, Bauru School of Dentistry, Bauru, SP, Brazil., Taira EA; Universidade de São Paulo - USP, Bauru School of Dentistry, Bauru, SP, Brazil., Ventura TMO; Universidade de São Paulo - USP, Bauru School of Dentistry, Bauru, SP, Brazil., Câmara JVF; Universidade de São Paulo - USP, Bauru School of Dentistry, Bauru, SP, Brazil., Araujo TT; Universidade de São Paulo - USP, Bauru School of Dentistry, Bauru, SP, Brazil., Magalhães AC; Universidade de São Paulo - USP, Bauru School of Dentistry, Bauru, SP, Brazil., Carvalho TS; University of Bern, Department of Preventive, Restorative and Pediatric Dentistry, Bern, Switzerland., Baumann T; University of Bern, Department of Preventive, Restorative and Pediatric Dentistry, Bern, Switzerland., Lussi A; University of Bern, Department of Preventive, Restorative and Pediatric Dentistry, Bern, Switzerland., Oliveira RB; Universidade de São Paulo - USP, Ribeirão Preto School of Medicine, Department of General Medicine, Ribeirão Preto, SP, Brazil., Palma-Dibb RG; Universidade de São Paulo - USP, Ribeirão Preto School of Medicine, Department of Restorative Dentistry, Ribeirão Preto, SP, Brazil., Buzalaf MAR; Universidade de São Paulo - USP, Bauru School of Dentistry, Bauru, SP, Brazil.
Jazyk: angličtina
Zdroj: Brazilian oral research [Braz Oral Res] 2023 Sep 15; Vol. 37, pp. e085. Date of Electronic Publication: 2023 Sep 15 (Print Publication: 2023).
DOI: 10.1590/1807-3107bor-2023.vol37.0085
Abstrakt: The objective of this study was to compare the protein profile of the acquired enamel pellicle (AEP) formed in vivo in patients with or without gastroesophageal reflux disease (GERD), and with or without erosive tooth wear (ETW). Twenty-four volunteers were divided into 3 groups: 1) GERD and ETW; 2) GERD without ETW; and 3) control (without GERD). The AEP formed 120 min after prophylaxis was collected from the lingual/palatal surfaces. The samples were subjected to mass spectrometry (nLC-ESI-MS/MS) and label-free quantification by Protein Lynx Global Service software. A total of 213 proteins were identified, or 119, 92 and 106 from each group, respectively. Group 2 showed a high number of phosphorylated and calcium-binding proteins. Twenty-three proteins were found in all the groups, including 14-3-3 protein zeta/delta and 1-phosphatidylinositol. Several intracellular proteins that join saliva after the exfoliation of oral mucosa cells might have the potential to bind hydroxyapatite, or participate in forming supramolecular aggregates that bind to precursor proteins in the AEP. Proteins might play a central role in protecting the dental surface against acid dissolution.
Databáze: MEDLINE
Externí odkaz: