Heterogeneity of the tumor immune microenvironment and clinical interventions.

Autor: Jin Z; Department of Oncology, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.; Key Laboratory of Tumor Immunotherapy, Chongqing, 400037, China.; Research Institute, GloriousMed Clinical Laboratory (Shanghai) Co. Ltd., Shanghai, 201318, China.; Institute of Life Sciences, Chongqing Medical University, Chongqing, 400016, China., Zhou Q; Department of Oncology, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.; Key Laboratory of Tumor Immunotherapy, Chongqing, 400037, China.; School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China., Cheng JN; Department of Oncology, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China. jeanna@foxmail.com.; Key Laboratory of Tumor Immunotherapy, Chongqing, 400037, China. jeanna@foxmail.com., Jia Q; Department of Oncology, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China. qingzhu.jia@tmmu.edu.cn.; Key Laboratory of Tumor Immunotherapy, Chongqing, 400037, China. qingzhu.jia@tmmu.edu.cn., Zhu B; Department of Oncology, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China. bo.zhu@tmmu.edu.cn.; Key Laboratory of Tumor Immunotherapy, Chongqing, 400037, China. bo.zhu@tmmu.edu.cn.
Jazyk: angličtina
Zdroj: Frontiers of medicine [Front Med] 2023 Aug; Vol. 17 (4), pp. 617-648. Date of Electronic Publication: 2023 Sep 20.
DOI: 10.1007/s11684-023-1015-9
Abstrakt: The tumor immune microenvironment (TIME) is broadly composed of various immune cells, and its heterogeneity is characterized by both immune cells and stromal cells. During the course of tumor formation and progression and anti-tumor treatment, the composition of the TIME becomes heterogeneous. Such immunological heterogeneity is not only present between populations but also exists on temporal and spatial scales. Owing to the existence of TIME, clinical outcomes can differ when a similar treatment strategy is provided to patients. Therefore, a comprehensive assessment of TIME heterogeneity is essential for developing precise and effective therapies. Facilitated by advanced technologies, it is possible to understand the complexity and diversity of the TIME and its influence on therapy responses. In this review, we discuss the potential reasons for TIME heterogeneity and the current approaches used to explore it. We also summarize clinical intervention strategies based on associated mechanisms or targets to control immunological heterogeneity.
(© 2023. Higher Education Press.)
Databáze: MEDLINE
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