Mass production of morin-stabilized silver nanoparticles: Characterization, antioxidant, and antimicrobial activities.

Autor: Zayed MF; Chemistry Department, Faculty of Science, Menoufia University, Shibin El Kom, Egypt., Abdel-Monem YK; Chemistry Department, Faculty of Science, Menoufia University, Shibin El Kom, Egypt., Arafa AA; Chemistry Department, Faculty of Science, Menoufia University, Shibin El Kom, Egypt., Eisa WH; Spectroscopy Department, Physics Research Institute, National Research Centre (NRC), Cairo, Egypt.
Jazyk: angličtina
Zdroj: Microscopy research and technique [Microsc Res Tech] 2024 Jan; Vol. 87 (1), pp. 149-158. Date of Electronic Publication: 2023 Sep 20.
DOI: 10.1002/jemt.24419
Abstrakt: Phytochemical-conjugated silver nanoparticles (AgNPs) are believed to act as a bridge between nanotechnology and therapy. There is a significant need for green and mass production of such materials due to their extensive applications, especially in the biomedical sector. In this study, morin-stabilized silver nanoparticles (morin/AgNPs) were synthesized on a massive scale using a one-pot solid-state technique. The reaction is achieved by ball milling of morin and silver nitrate powders at ambient temperature without any solvent or toxic reagent. The prepared morin/AgNPs exhibited a semi-hexagonal shape and ranged in size from 21 to 43 nm. The x-ray diffraction results elucidated the formation of highly crystalline AgNPs. Fourier transform infrared and x-ray photoelectron spectroscopic analyses prove that the hydroxyl, carbonyl, and aromatic functionalities in morin are playing major roles in the reduction and stabilization of AgNPs. The antioxidant potential of morin/AgNPs was evaluated utilizing 2,2-Diphenyl-1-picryl-hydrazyl (DPPH) assay. Morin/AgNPs exhibited better free radical scavenging activity (IC 50  = 11.7 μg/mL) than morin (IC 50  = 14.8 μg/mL). Furthermore, the synthesized AgNPs showed promising antimicrobial activity against Escherichia coli, Klebsiella pneumonia, Staphylococcus aureus, Streptococcus mutans, and Candida albicans. The largest inhibition zones were observed against S. aureus (21.2 ± 0.6 mm) and K. pneumonia (20.3 ± 0.5 mm) bacteria. The foregoing results highlighted the prospective application of morin/AgNPs as a promising antioxidant and antimicrobial material for safe medical applications. RESEARCH HIGHLIGHTS: A simple green route for the large-scale production of AgNPs was developed. Morin acts as reducing/stabilizing agent in solid-state synthesis of AgNPs. Morin/AgNPs exhibited promising antimicrobial and antioxidant activity.
(© 2023 Wiley Periodicals LLC.)
Databáze: MEDLINE
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