Pulmonary involvement from animal toxins: the cellular mechanisms.
| Autor: | Thumtecho S; Division of Toxicology, Department of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, the Thai Red Cross Society, Bangkok, Thailand., Suteparuk S; Division of Toxicology, Department of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, the Thai Red Cross Society, Bangkok, Thailand., Sitprija V; Queen Saovabha Memorial Institute and King Chulalongkorn Memorial Hospital, the Thai Red Cross Society, Bangkok, Thailand. |
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| Jazyk: | angličtina |
| Zdroj: | The journal of venomous animals and toxins including tropical diseases [J Venom Anim Toxins Incl Trop Dis] 2023 Sep 18; Vol. 29, pp. e20230026. Date of Electronic Publication: 2023 Sep 18 (Print Publication: 2023). |
| DOI: | 10.1590/1678-9199-JVATITD-2023-0026 |
| Abstrakt: | Venomous animals and their venom have always been of human interest because, despite species differences, coevolution has made them capable of targeting key physiological components of our bodies. Respiratory failure from lung injury is one of the serious consequences of envenomation, and the underlying mechanisms are rarely discussed. This review aims to demonstrate how toxins affect the pulmonary system through various biological pathways. Herein, we propose the common underlying cellular mechanisms of toxin-induced lung injury: interference with normal cell function and integrity, disruption of normal vascular function, and provocation of excessive inflammation. Viperid snakebites are the leading cause of envenomation-induced lung injury, followed by other terrestrial venomous animals such as scorpions, spiders, and centipedes. Marine species, particularly jellyfish, can also inflict such injury. Common pulmonary manifestations include pulmonary edema, pulmonary hemorrhage, and exudative infiltration. Severe envenomation can result in acute respiratory distress syndrome. Pulmonary involvement suggests severe envenomation, thus recognizing these mechanisms and manifestations can aid physicians in providing appropriate treatment. Competing Interests: Competing interests: The authors declare that they have no competing interests. |
| Databáze: | MEDLINE |
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