Social and psychological adversity are associated with distinct mother and infant gut microbiome variations.

Autor: Warner BB; Department of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MO, 63110, USA. warnerbb@wustl.edu., Rosa BA; Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO, 63110, USA., Ndao IM; Department of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MO, 63110, USA., Tarr PI; Department of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MO, 63110, USA.; Department of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, MO, 63110, USA., Miller JP; Institute for Informatics, Data Science and Biostatistics, Washington University School of Medicine in St. Louis, St. Louis, MO, 63110, USA., England SK; Department of Obstetrics and Gynecology, Center for Reproductive Health Sciences, Washington University School of Medicine in St. Louis, St. Louis, MO, 63110, USA., Luby JL; Department of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO, 63110, USA., Rogers CE; Departments of Psychiatry and Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MO, 63110, USA., Hall-Moore C; Department of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MO, 63110, USA., Bryant RE; Department of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MO, 63110, USA., Wang JD; Department of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MO, 63110, USA., Linneman LA; Department of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MO, 63110, USA., Smyser TA; Department of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO, 63110, USA., Smyser CD; Departments of Neurology, Pediatrics and Radiology, Washington University School of Medicine in St. Louis, St. Louis, MO, 63110, USA., Barch DM; Department of Psychological and Brain Sciences, Psychiatry, & Radiology, Washington University in St. Louis, St. Louis, MO, 63130, USA., Miller GE; Institute for Policy Research & Department of Psychology, Northwestern University, Evanston, IL, 60208, USA., Chen E; Institute for Policy Research & Department of Psychology, Northwestern University, Evanston, IL, 60208, USA., Martin J; Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO, 63110, USA., Mitreva M; Departments of Medicine and Genetics, and McDonnell Genome Institute, Washington University School of Medicine in St. Louis, St. Louis, MO, 63110, USA. mmitreva@wustl.edu.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2023 Sep 20; Vol. 14 (1), pp. 5824. Date of Electronic Publication: 2023 Sep 20.
DOI: 10.1038/s41467-023-41421-4
Abstrakt: Health disparities are driven by underlying social disadvantage and psychosocial stressors. However, how social disadvantage and psychosocial stressors lead to adverse health outcomes is unclear, particularly when exposure begins prenatally. Variations in the gut microbiome and circulating proinflammatory cytokines offer potential mechanistic pathways. Here, we interrogate the gut microbiome of mother-child dyads to compare high-versus-low prenatal social disadvantage, psychosocial stressors and maternal circulating cytokine cohorts (prospective case-control study design using gut microbiomes from 121 dyads profiled with 16 S rRNA sequencing and 89 dyads with shotgun metagenomic sequencing). Gut microbiome characteristics significantly predictive of social disadvantage and psychosocial stressors in the mothers and children indicate that different discriminatory taxa and related pathways are involved, including many species of Bifidobacterium and related pathways across several comparisons. The lowest inter-individual gut microbiome similarity was observed among high-social disadvantage/high-psychosocial stressors mothers, suggesting distinct environmental exposures driving a diverging gut microbiome assembly compared to low-social disadvantage/low-psychosocial stressors controls (P = 3.5 × 10 -5 for social disadvantage, P = 2.7 × 10 -15 for psychosocial stressors). Children's gut metagenome profiles at 4 months also significantly predicted high/low maternal prenatal IL-6 (P = 0.029), with many bacterial species overlapping those identified by social disadvantage and psychosocial stressors. These differences, based on maternal social and psychological status during a critical developmental window early in life, offer potentially modifiable targets to mitigate health inequities.
(© 2023. Springer Nature Limited.)
Databáze: MEDLINE
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