Association Between the Appendicular Extracellular-to-Intracellular Water Ratio and All-Cause Mortality: A 10-Year Longitudinal Study.

Autor:	Iwasaka C; Department of Physical Activity Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.; Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan., Yamada Y; Department of Physical Activity Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.; Laboratory of Gut Microbiome for Health, Microbial Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan., Nishida Y; Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan., Hara M; Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan., Yasukata J; Department of Sports and Health Sciences, Faculty of Human Sciences, University of East Asia, Yamaguchi, Japan., Miyoshi N; Department of Childhood Care Education, Seika Women's Junior College, Fukuoka, Japan., Shimanoe C; Department of Pharmacy, Saga University Hospital, Saga, Japan., Nanri H; Department of Physical Activity Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.; Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan.; Laboratory of Gut Microbiome for Health, Microbial Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan., Furukawa T; Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan.; Clinical Research Center, Saga University Hospital, Saga, Japan., Koga K; Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan.; Department of Nursing, Faculty of Medicine, Fukuoka University, Fukuoka, Japan., Horita M; Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan., Higaki Y; Laboratory of Exercise Physiology, Faculty of Sports and Health Science, Fukuoka University, Fukuoka, Japan., Tanaka K; Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan.
Jazyk:	angličtina
Zdroj:	The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2024 Feb 01; Vol. 79 (2).
DOI:	10.1093/gerona/glad211
Abstrakt:	The appendicular extracellular-to-intracellular water ratio (A-E/I) is a potential marker of skeletal muscle quality, reflecting the balance of water distribution between the extracellular and intracellular compartments of the appendicular limb regions. A-E/I has been increasingly used in recent studies; however, its association with adverse outcomes remains unclear. This study investigated the potential association between A-E/I and all-cause mortality. A prospective cohort study of 8 015 middle-aged and older adults (comprised of 4 755 women, aged 45-74 years) residing in a Japanese community was conducted. The baseline assessment was performed between 2010 and 2012, and the follow-up period lasted until July 2022. A-E/I and skeletal muscle mass were measured using segmental bioelectrical impedance spectroscopy. Handgrip strength (HGS) was measured using a Smedley-type dynamometer. Lifestyle, medical history, and physical activity were assessed by questionnaire and accelerometer. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) for each quartile (Q) of A-E/I were estimated using the multivariable Cox regression model. During a 10.5-year median follow-up, the mortality rates were 8.9 and 3.6 per 1 000 person-years for men (292 deaths) and women (174 deaths), respectively. A-E/I quartiles were positively associated with all-cause mortality in both sexes (men: Q1, HR: 1.0 [95% CI: reference], Q4, HR: 1.8 [1.1-2.9], ptrend < .05; women, Q4, HR: 2.2 [1.3-3.8], ptrend < .01). This association remained significant after further adjustment for skeletal muscle mass and HGS (ptrend < .05). Our findings suggest that A-E/I serves as an early predictive marker for mortality in middle-aged and older Japanese adults. (© The Author(s) 2023. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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