Platelet distribution width (PDW) as a significant correlate of COVID-19 infection severity and mortality.

Autor:	Ligi D; Laboratories of Clinical Biochemistry, Section of Biochemistry and Biotechnology, Department of Biomolecular Sciences - DISB, University of Urbino Carlo Bo, Urbino, Italy., Della Franca C; Laboratories of Clinical Biochemistry, Section of Biochemistry and Biotechnology, Department of Biomolecular Sciences - DISB, University of Urbino Carlo Bo, Urbino, Italy., Notarte KI; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Goldrich N; New York Medical College, Valhalla, NY, USA., Kavteladze D; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA., Henry BM; Clinical Laboratory, Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Mannello F; Laboratories of Clinical Biochemistry, Section of Biochemistry and Biotechnology, Department of Biomolecular Sciences - DISB, University of Urbino Carlo Bo, Urbino, Italy.
Jazyk:	angličtina
Zdroj:	Clinical chemistry and laboratory medicine [Clin Chem Lab Med] 2023 Sep 20; Vol. 62 (3), pp. 385-395. Date of Electronic Publication: 2023 Sep 20 (Print Publication: 2024).
DOI:	10.1515/cclm-2023-0625
Abstrakt:	SARS-CoV-2 infection may cause a wide spectrum of symptoms, from asymptomatic, to mild respiratory symptoms and life-threatening sepsis. Among the clinical laboratory biomarkers analyzed during COVID-19 pandemic, platelet indices have raised great interest, due to the critical involvement of platelets in COVID-19-related thromboinflammation. Through an electronic literature search on MEDLINE, CINAHL, PubMed, EMBASE, Web of Science, and preprint servers we performed and updated a systematic review aimed at providing a detailed analysis of studies addressing the potential clinical utility of platelet distribution width, platelet distribution width (PDW), in laboratory medicine, exploring the possible association between increased PDW levels, disease severity, and mortality in COVID-19. Our systematic review revealed a wide heterogeneity of COVID-19 cohorts examined and a lack of homogenous expression of platelet indices. We found that 75 % of studies reported significantly elevated PDW values in COVID-19 infected cohorts compared to healthy/non-COVID-19 controls, and 40 % of studies reported that patients with severe COVID-19 showed increased PDW values than those with less-than-severe illness. Interestingly, 71.4 % of studies demonstrated significant increased PDW values in non survivors vs. survivors. Overall, these results suggest that platelets are critically involved as major players in the process of immunothrombosis in COVID-19, and platelet reactivity and morphofunctional alterations are mirrored by PDW, as indicator of platelet heterogeneity. Our results confirm that the use of PDW as prognostic biomarkers of COVID-19 sepsis still remains debated due to the limited number of studies to draw a conclusion, but new opportunities to investigate the crucial role of platelets in thrombo-inflammation are warranted. (© 2023 Walter de Gruyter GmbH, Berlin/Boston.)
Databáze:	MEDLINE
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