AtopyReg ® , the Prospective Italian Patient Registry for Moderate-to-Severe Atopic Dermatitis in Adults: Baseline Demographics, Disease Characteristics, Comorbidities, and Treatment History.

Autor: Stingeni L; Dermatology Section, Department of Medicine and Surgery, University of Perugia, Perugia, Italy. luca.stingeni@unipg.it., Chiricozzi A; UOC di Dermatologia, Dipartimento Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.; Dermatologia, Dipartimento Universitario di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy., Calzavara-Pinton P; Department of Dermatology, ASST Spedali Civili di Brescia, University of Brescia, Brescia, Italy., Napolitano M; Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy., Peris K; UOC di Dermatologia, Dipartimento Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Schena D; Section of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, Italy., Patruno C; Section of Dermatology, Health Sciences Department, Magna Graecia University, Catanzaro, Italy., Rossi M; Department of Dermatology, ASST Spedali Civili di Brescia, University of Brescia, Brescia, Italy., Foti C; Department of Emergency and Organ Transplantation, Allergology and Clinical Immunology, University of Bari, Bari, Italy., Fargnoli MC; Dermatology, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy., Corazza M; Section of Dermatology, Department of Medical Sciences, University of Ferrara, Ferrara, Italy., Ferrucci SM; Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Pigatto PD; Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy., Romanelli M; Dermatology Unit, University of Pisa, Pisa, Italy., Fabbrocini G; Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy., Girolomoni G; Section of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, Italy., Passante M; Section of Dermatology, Health Sciences Department, Magna Graecia University, Catanzaro, Italy., Romita P; Department of Emergency and Organ Transplantation, Allergology and Clinical Immunology, University of Bari, Bari, Italy., Esposito M; Dermatology, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy., Schettini N; Section of Dermatology, Department of Medical Sciences, University of Ferrara, Ferrara, Italy., Marzano AV; Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy., Tonini G; Dermatology Unit, University of Pisa, Pisa, Italy., Marietti R; Dermatology Section, Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Casciola G; Dermatology Section, Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Argenziano G; Dermatology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Naples, Italy., Hansel K; Dermatology Section, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Jazyk: angličtina
Zdroj: American journal of clinical dermatology [Am J Clin Dermatol] 2024 Jan; Vol. 25 (1), pp. 149-160. Date of Electronic Publication: 2023 Sep 19.
DOI: 10.1007/s40257-023-00819-y
Abstrakt: Background and Objective: AtopyReg ® is a multicenter, prospective, observational, non-profit cohort study on moderate-to-severe atopic dermatitis in adults promoted in 2018 by the Italian Society of Dermatology and Venereology (SIDeMaST). We aimed to describe baseline demographics, disease characteristics, comorbidities, and therapeutic data of adult patients affected by moderate-to-severe atopic dermatitis.
Methods: Patients were selected based on the following inclusion criteria: age ≥ 18 years; Eczema Area and Severity Index score ≥ 16 or localization in visible or sensitive areas (face, neck, hands, or genitalia), or a Numeric Rating Scale itch score ≥ 7 or a Numeric Rating Scale sleep loss score ≥ 7, or a Dermatology Life Quality Index score ≥ 10. Demographic and clinical data at baseline were recorded and analyzed.
Results: A total of 1170 patients (male 51.1%; mean age: 44.7 years; range 18-90 years) were enrolled by 12 Italian Dermatology Units between January 2019 and November 2022. Skin lesions were eczematous in 83.2% of patients, the most involved site were the flexures (53.9%), face (50.9%), and neck (48.0%). Mean Eczema Area and Severity Index score was 22.3, mean Dermatology Life Quality Index value was 17.6, mean Patient Oriented Eczema Measure score was 13.1, and mean Numeric Rating Scale itch and sleep loss scores were 7.6 and 5.9, respectively. Previous systemic therapies were corticosteroids in 77.7% of patients, antihistamines in 50.3% of patients, and cyclosporine A in 42.6% of patients.
Conclusions: This baseline data analysis deriving from AtopyReg ® provides real-life evidence on patients with moderate-to-severe atopic dermatitis in Italy confirming the high burden of atopic dermatitis with a significant impact on patients' quality of life.
(© 2023. The Author(s).)
Databáze: MEDLINE
Externí odkaz: