| Autor: |
Thrinadh Kumar R; Department of Chemistry, School of Applied Science and Humanities, Vignan's Foundation for Science Technology and Research, Vadlamudi, Guntur, Andhra Pradesh 522213, India. ravikottalanka@gmail.com.; Aragen Life Sciences Ltd, 28A, IDA Nacharam, Hyderabad, Telangana-500076, India., Makam P; Department of Chemistry, School of Applied and Life Sciences, Uttaranchal University, Arcadia Grant, P.O. Chandanwari, Premnagar, Dehradun, Uttarakhand-248007, India., Katari NK; Department of Chemistry, GITAM School of Science, GITAM Deemed to be University, Hyderabad, Telangana-502329, India. nkatari@gitam.edu., Kottalanka RK; Department of Chemistry, School of Applied Science and Humanities, Vignan's Foundation for Science Technology and Research, Vadlamudi, Guntur, Andhra Pradesh 522213, India. ravikottalanka@gmail.com. |
| Abstrakt: |
A new approach has been successfully employed to synthesize cyclic ureas via carbonylation, utilizing Boc anhydride and employing K 2 CO 3 as a base along with N , N -dimethylformamide as the solvent. Remarkably high yields were achieved using K 2 CO 3 in conjunction with (Boc) 2 O, enabling the streamlined preparation of benzimidazolones and 2-benzoxazolones within a single reaction vessel. Significantly, this approach obviates the necessity for using any dangerous reagents, rendering it environmentally friendly, and its key benefit lies in being a metal-free system. The method stands out for its efficiency, concise pathway, optimization from readily accessible starting materials, and ease of execution. The resulting benzimidazolones and 2-benzoxazolones were thoroughly characterized using techniques including LCMS, 1 H NMR, and 13 C NMR. |
