Genetic Influences on Outcomes of Psychotherapy in Borderline Personality Disorder: A Narrative Review of Implications for Personalized Treatment.
| Autor: | Ansari D; Psychiatry, Islamabad Medical and Dental College, Islamabad, PAK., Lakkimsetti M; Internal Medicine, Mamata Medical College, Khammam, IND., Olaleye KT; Neurological Sciences, AdventHealth Tampa, Tampa, USA., Bhullar JVK; Psychiatry, Government Medical College, Patiala, Patiala, IND., Shah RZ; Psychiatry and Behavioral Sciences, Dow University of Health Sciences, Karachi, PAK., Arisoyin AE; Internal Medicine, College of Medicine, University of Lagos, Lagos, NGA., Nadeem H; Psychiatry, Combined Military Hospital (CMH) Lahore Medical College, Lahore, PAK., Sacal Slovik SC; Neuroscience, Boston University School of Medicine, Boston, USA., Habib FZ; Programs & Research, SHINE Humanity, Karachi, PAK., Abdin ZU; Medicine, District Head Quarter Hospital, Faisalabad, PAK., Zia Ul Haq M; Epidemiology and Public Health, Emory University Rollins School of Public Health, Atlanta, USA.; Noncommunicable Diseases and Mental Health, World Health Organization, Cairo, EGY. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2023 Aug 18; Vol. 15 (8), pp. e43702. Date of Electronic Publication: 2023 Aug 18 (Print Publication: 2023). |
| DOI: | 10.7759/cureus.43702 |
| Abstrakt: | Borderline personality disorder (BPD) manifests as instability in mood, relationships, self-image, and behavior, representing a challenging mental health issue. This review scrutinizes genetic factors influencing BPD and the corresponding treatment outcomes. The primary objective of this narrative review is to illuminate the association between genetic factors and BPD treatment outcomes, discussing the potential of genetic testing for personalized therapy. The review is derived from observational and experimental studies on BPD, genetic factors, and psychotherapy from 2000 to 2023, sourced primarily through PubMed. Reviews and meta-analyses were excluded. Our review suggests that genetic factors account for 40-60% of BPD variation, with significant roles played by epigenetic alterations like DNA methylation and microRNAs, particularly in the context of childhood trauma. Gene-environment interactions are also vital for BPD's development. Treatments such as dialectical behavior therapy, mentalization-based therapy, and schema therapy have shown efficacy, with success variability possibly linked to genetic factors. However, existing research is constrained by recall bias, diverse methodologies, and limited sample sizes. Future research necessitates long-term follow-up, diverse populations, and controlled variables to enhance our comprehension of BPD treatment outcomes' genetic foundations. The review underlines the promise of personalized medicine in BPD treatment, driven by genetic insights. Competing Interests: The authors have declared financial relationships, which are detailed in the next section. (Copyright © 2023, Ansari et al.) |
| Databáze: | MEDLINE |
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