Towards multifunctional robotic pills.

Autor: Mundaca-Uribe R; Department of Nanoengineering and Chemical Engineering Program, University of California San Diego, La Jolla, CA, USA., Askarinam N; Department of Nanoengineering and Chemical Engineering Program, University of California San Diego, La Jolla, CA, USA., Fang RH; Department of Nanoengineering and Chemical Engineering Program, University of California San Diego, La Jolla, CA, USA., Zhang L; Department of Nanoengineering and Chemical Engineering Program, University of California San Diego, La Jolla, CA, USA. zhang@ucsd.edu., Wang J; Department of Nanoengineering and Chemical Engineering Program, University of California San Diego, La Jolla, CA, USA. josephwang@ucsd.edu.
Jazyk: angličtina
Zdroj: Nature biomedical engineering [Nat Biomed Eng] 2024 Nov; Vol. 8 (11), pp. 1334-1346. Date of Electronic Publication: 2023 Sep 18.
DOI: 10.1038/s41551-023-01090-6
Abstrakt: Robotic pills leverage the advantages of oral pharmaceutical formulations-in particular, convenient encapsulation, high loading capacity, ease of manufacturing and high patient compliance-as well as the multifunctionality, increasing miniaturization and sophistication of microrobotic systems. In this Perspective, we provide an overview of major innovations in the development of robotic pills-specifically, oral pills embedded with robotic capabilities based on microneedles, microinjectors, microstirrers or microrockets-summarize current progress and applicational gaps of the technology, and discuss its prospects. We argue that the integration of multiple microrobotic functions within oral delivery systems alongside accurate control of the release characteristics of their payload provides a basis for realizing sophisticated multifunctional robotic pills that operate as closed-loop systems.
Competing Interests: Competing interests: The authors declare no competing interests.
(© 2023. Springer Nature Limited.)
Databáze: MEDLINE
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