A biobank of pediatric patient-derived-xenograft models in cancer precision medicine trial MAPPYACTS for relapsed and refractory tumors.

Autor: Marques Da Costa ME; INSERM U1015, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France.; Department of Pediatric and Adolescent Oncology, Gustave Roussy Cancer Campus, Villejuif, France., Zaidi S; INSERM U830, Equipe Labellisée LNCC, Diversity and Plasticity of Childhood Tumors Lab, PSL Research University, SIREDO Oncology Centre, Institut Curie Research Centre, Paris, France., Scoazec JY; Department of Pathology and Laboratory Medicine, Translational Research Laboratory and Biobank, AMMICA, INSERM US23/CNRS UMS3655, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France., Droit R; INSERM U1015, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France.; Gustave Roussy Cancer Campus, Bioinformatics Platform, AMMICA, INSERM US23/CNRS, UAR3655, Villejuif, France., Lim WC; INSERM U1015, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France.; School of Data Sciences, Perdana University, Kuala Lumpur, Malaysia., Marchais A; INSERM U1015, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France.; Department of Pediatric and Adolescent Oncology, Gustave Roussy Cancer Campus, Villejuif, France., Salmon J; INSERM U1015, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France., Cherkaoui S; INSERM U1015, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France.; Division of Oncology and Children's Research Center, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland., Morscher RJ; INSERM U1015, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France.; Division of Oncology and Children's Research Center, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland., Laurent A; Gustave Roussy Cancer Campus, INSERM U1170, Université Paris-Saclay, Equipe labellisée Ligue Nationale Contre le Cancer, PEDIAC program, Villejuif, France., Malinge S; Gustave Roussy Cancer Campus, INSERM U1170, Université Paris-Saclay, Equipe labellisée Ligue Nationale Contre le Cancer, PEDIAC program, Villejuif, France.; Telethon Kids Institute - Cancer Centre, Perth Children's Hospital, Nedlands, WA, Australia., Mercher T; Gustave Roussy Cancer Campus, INSERM U1170, Université Paris-Saclay, Equipe labellisée Ligue Nationale Contre le Cancer, PEDIAC program, Villejuif, France., Tabone-Eglinger S; Biological Ressources Center, Centre Léon Bérard, Lyon, France., Goddard I; Small Animal Platform, Cancer Research Center of Lyon, INSERM U1052, CNRS UMR 5286, Centre Léon Bérard, Claude Bernard Université Lyon 1, Lyon, France., Pflumio F; UMR-E008 Stabilité Génétique, Cellules Souches et Radiations, Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), Université de Paris-Université Paris-Saclay, 92260, Fontenay-aux-Roses, France., Calvo J; UMR-E008 Stabilité Génétique, Cellules Souches et Radiations, Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), Université de Paris-Université Paris-Saclay, 92260, Fontenay-aux-Roses, France., Redini F; INSERM UMR 1238, Université Nantes, Nantes, France., Entz-Werlé N; Pediatric Onco-Hematology Unit, University Hospital of Strasbourg, Strasbourg, UMR CNRS 7021, team tumoral signaling and therapeutic targets, University of Strasbourg, Faculty of Pharmacy, Illkirch, France., Soriano A; Vall d'Hebron Research Institute (VHIR), Childhood Cancer and Blood Disorders Research Group, Division of Pediatric Hematology and Oncology, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain., Villanueva A; Chemoresistance and Predictive Factors Group, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet del Llobregat, Xenopat SL, Parc Cientific de Barcelona (PCB), Barcelona, Spain., Cairo S; XenTech, Evry, France., Chastagner P; Children University Hospital, Vandoeuvre‑lès‑Nancy, University of Nancy, Nancy, France., Moro M; Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Owens C; Paediatric Haematology/Oncology, Children's Health Ireland, Crumlin, Dublin, Republic of Ireland., Casanova M; Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Hladun-Alvaro R; Vall d'Hebron Research Institute (VHIR), Childhood Cancer and Blood Disorders Research Group, Division of Pediatric Hematology and Oncology, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain., Berlanga P; Department of Pediatric and Adolescent Oncology, Gustave Roussy Cancer Campus, Villejuif, France., Daudigeos-Dubus E; INSERM U1015, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France., Dessen P; INSERM U1015, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France.; Gustave Roussy Cancer Campus, Bioinformatics Platform, AMMICA, INSERM US23/CNRS, UAR3655, Villejuif, France., Zitvogel L; INSERM U1015, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France., Lacroix L; Department of Pathology and Laboratory Medicine, Translational Research Laboratory and Biobank, AMMICA, INSERM US23/CNRS UMS3655, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France., Pierron G; Unité de Génétique Somatique, Service d'oncogénétique, Institut Curie, Paris, France., Delattre O; INSERM U830, Equipe Labellisée LNCC, Diversity and Plasticity of Childhood Tumors Lab, PSL Research University, SIREDO Oncology Centre, Institut Curie Research Centre, Paris, France.; Unité de Génétique Somatique, Service d'oncogénétique, Institut Curie, Paris, France.; SiRIC RTOP (Recherche Translationnelle en Oncologie Pédiatrique); Translational Research Department, Institut Curie Research Center, PSL Research University, Institut Curie, Paris, France., Schleiermacher G; INSERM U830, Equipe Labellisée LNCC, Diversity and Plasticity of Childhood Tumors Lab, PSL Research University, SIREDO Oncology Centre, Institut Curie Research Centre, Paris, France.; SiRIC RTOP (Recherche Translationnelle en Oncologie Pédiatrique); Translational Research Department, Institut Curie Research Center, PSL Research University, Institut Curie, Paris, France., Surdez D; INSERM U830, Equipe Labellisée LNCC, Diversity and Plasticity of Childhood Tumors Lab, PSL Research University, SIREDO Oncology Centre, Institut Curie Research Centre, Paris, France.; Balgrist University Hospital, University of Zurich, Zurich, Switzerland., Geoerger B; INSERM U1015, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France. birgit.geoerger@gustaveroussy.fr.; Department of Pediatric and Adolescent Oncology, Gustave Roussy Cancer Campus, Villejuif, France. birgit.geoerger@gustaveroussy.fr.
Jazyk: angličtina
Zdroj: Communications biology [Commun Biol] 2023 Sep 18; Vol. 6 (1), pp. 949. Date of Electronic Publication: 2023 Sep 18.
DOI: 10.1038/s42003-023-05320-0
Abstrakt: Pediatric patients with recurrent and refractory cancers are in most need for new treatments. This study developed patient-derived-xenograft (PDX) models within the European MAPPYACTS cancer precision medicine trial (NCT02613962). To date, 131 PDX models were established following heterotopical and/or orthotopical implantation in immunocompromised mice: 76 sarcomas, 25 other solid tumors, 12 central nervous system tumors, 15 acute leukemias, and 3 lymphomas. PDX establishment rate was 43%. Histology, whole exome and RNA sequencing revealed a high concordance with the primary patient's tumor profile, human leukocyte-antigen characteristics and specific metabolic pathway signatures. A detailed patient molecular characterization, including specific mutations prioritized in the clinical molecular tumor boards are provided. Ninety models were shared with the IMI2 ITCC Pediatric Preclinical Proof-of-concept Platform (IMI2 ITCC-P4) for further exploitation. This PDX biobank of unique recurrent childhood cancers provides an essential support for basic and translational research and treatments development in advanced pediatric malignancies.
(© 2023. Springer Nature Limited.)
Databáze: MEDLINE
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