Vitamin D Deficiency is Associated With Increased Plasminogen Activator Inhibitor 1/Plasminogen Activator Inhibitor 2 Ratio in Pregnancy.

Autor:	Andersen MK; Department of Obstetrics and Gynecology, Randers Regional Hospital, Randers, Denmark.; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Rüdiger IH; Department of Obstetrics and Gynecology, Randers Regional Hospital, Randers, Denmark., Vestergaard AL; Department of Obstetrics and Gynecology, Randers Regional Hospital, Randers, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Palarasah Y; Department of Molecular Medicine, Research Unit for Cancer and Inflammation, University of Southern Denmark, Odense, Denmark., Bor P; Department of Obstetrics and Gynecology, Randers Regional Hospital, Randers, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Larsen A; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Bor MV; Department of Regional Health Research, Thrombosis Research, University of Southern Denmark, Esbjerg, Denmark.; Department of Clinical Biochemistry, University Hospital of Southern Denmark, Esbjerg, Denmark.
Jazyk:	angličtina
Zdroj:	Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis [Clin Appl Thromb Hemost] 2023 Jan-Dec; Vol. 29, pp. 10760296231201855.
DOI:	10.1177/10760296231201855
Abstrakt:	Background: Vitamin D deficiency has recently been suggested as an independent risk factor for thrombosis. Notably, vitamin D deficiency is common in pregnant populations, whom already have an increased thrombotic risk. However, pregnant women are commonly excluded from studies investigating the hemostatic system, and knowledge on the impact of vitamin D on hemostasis in pregnancy is therefore limited. Methods: A cross-sectional study comparing the hemostatic profile of pregnant women (gestational week 12.9 ± 0.7) with vitamin D deficiency (≤50 nmol/L) (n = 70) and high adequate vitamin D status (≥100 nmol/L) (n = 59). Results: Vitamin D deficient women displayed increased plasminogen activator inhibitor 1 levels and an increased plasminogen activator inhibitor 1/plasminogen activator inhibitor 2 ratio, even after adjusting for factors with potential influence on hemostasis (body mass index, smoking and use of fish oil supplements). Conclusions: Vitamin D deficiency is associated with increased plasminogen activator inhibitor 1/plasminogen activator inhibitor 2 ratio in pregnant women. As an increased plasminogen activator inhibitor 1/plasminogen activator inhibitor 2 ratio with high plasminogen activator inhibitor 1 levels may increase thrombotic risk and is associated with the development of pregnancy complications, further research is needed to determine the optimal vitamin D supplementation in pregnancy.
Databáze:	MEDLINE
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