Breaking barriers: bilosomes gel potentials to pave the way for transdermal breast cancer treatment with Tamoxifen.

Autor:	Abou Assi R; Thoughts Formulation Lab, Discipline of Pharmaceutical Technology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.; EDEN Research Group, Discipline of Pharmaceutical Technology, College of Pharmacy, Al-Kitab University, Kirkuk, Iraq., Abdulbaqi IM; Thoughts Formulation Lab, Discipline of Pharmaceutical Technology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.; PractSol Research Group, College of Pharmacy, Al-Kitab University, Kirkuk, Iraq.; Pharmaceutical Design and Simulation (PhDS) Lab, Discipline of Pharmaceutical Technology, School of Pharmaceutical Sciences, University Sains Malaysia, Minden, Penang, Malaysia., Tan SM; Thoughts Formulation Lab, Discipline of Pharmaceutical Technology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia., Wahab HA; Pharmaceutical Design and Simulation (PhDS) Lab, Discipline of Pharmaceutical Technology, School of Pharmaceutical Sciences, University Sains Malaysia, Minden, Penang, Malaysia., Darwis Y; Thoughts Formulation Lab, Discipline of Pharmaceutical Technology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia., Chan SY; Thoughts Formulation Lab, Discipline of Pharmaceutical Technology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.
Jazyk:	angličtina
Zdroj:	Drug development and industrial pharmacy [Drug Dev Ind Pharm] 2023 Sep 18, pp. 1-12. Date of Electronic Publication: 2023 Sep 18.
DOI:	10.1080/03639045.2023.2256404
Abstrakt:	Objective: Breast cancer affects women globally, regardless of age or location. On the other hand, Tamoxifen (TXN), a class II biopharmaceutical drug is acting as a prophylactic/treating agent for women at risk of and/or with hormone receptor-positive breast cancer. However, its oral administration has life-threatening side effects, which have led researchers to investigate alternative delivery methods. One such method is transdermal drug delivery utilizing bile salts as penetration enhancers, aka Bilosomes. Methods: Bilosomes formulations were optimized statistically for the outcome of vesicle shape, size, and entrapment efficiency using two types of bile, i.e. sodium taurocholate and sodium cholate. These bilosomes were then loaded into HPMC base gel and further characterized for their morphology, drug content, pH, viscosity, spreadability and eventually ex-vivo skin penetration and deposition studies. Results: Findings showed that sodium cholate has superiority as a penetration enhancer over sodium taurocholate in terms of morphological characterizes, zeta potential, and cumulative amounts of tamoxifen permeated per unit area (15.13 ± 0.71 μg/cm 2 and 6.51 ± 0.6 μg/cm 2 respectively). In fact, bilosomes designed with sodium cholate provided around 9 folds of skin deposition compared to TXN non-bilosomal gel. Conclusion: Bilosomes gels could be a promising option for locally delivering tamoxifen to the breast through the skin, offering an encouraging transdermal solution.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu